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Journal | Chemistry - A European Journal |
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Date | Accepted/In press - 28 Sep 2018 |
Date | E-pub ahead of print - 5 Oct 2018 |
Date | Published (current) - 23 Nov 2018 |
Issue number | 65 |
Volume | 24 |
Number of pages | 5 |
Pages (from-to) | 17210-17214 |
Early online date | 5/10/18 |
Original language | English |
A deaminative strategy for the borylation of aliphatic primary amines is described. Alkyl radicals derived from the single-electron reduction of redox-active pyridinium salts, which can be isolated or generated in situ, were borylated in a visible light-mediated reaction with bis(catecholato)diboron. No catalyst or further additives were required. The key electron donor–acceptor complex was characterized in detail by both experimental and computational investigations. The synthetic potential of this mild protocol was demonstrated through the late-stage functionalization of natural products and drug molecules.
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