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From the same journal

Deaminative Borylation of Aliphatic Amines Enabled by Visible Light Excitation of an Electron Donor–Acceptor Complex

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Author(s)

  • Frederik Sandfort
  • Felix Strieth-Kalthoff
  • Felix J.R. Klauck
  • Michael J. James
  • Frank Glorius

Department/unit(s)

Publication details

JournalChemistry - A European Journal
DateAccepted/In press - 28 Sep 2018
DatePublished (current) - 5 Oct 2018
Issue number65
Volume24
Number of pages5
Pages (from-to)17210-17214
Original languageEnglish

Abstract

A deaminative strategy for the borylation of aliphatic primary amines is described. Alkyl radicals derived from the single-electron reduction of redox-active pyridinium salts, which can be isolated or generated in situ, were borylated in a visible light-mediated reaction with bis(catecholato)diboron. No catalyst or further additives were required. The key electron donor–acceptor complex was characterized in detail by both experimental and computational investigations. The synthetic potential of this mild protocol was demonstrated through the late-stage functionalization of natural products and drug molecules.

    Research areas

  • borylation, deaminative strategy, DFT calculations, electron donor–acceptor, visible light

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