Projects per year
Abstract
Unfunctionalized indoles can be directly converted into 3,3'-spirocyclic indolenines and indolines upon reaction with electrophilic dihalides in the presence of t-BuOK/BEt3. This double C-C bond forming reaction, which simultaneously generates a quaternary spirocyclic center, typically proceeds in high yield and has good functional group tolerance. In contrast to existing dearomatizing spirocyclization approaches, there is no need to prepare a prefunctionalized aromatic precursor, enabling faster access to valuable spirocyclic products from simple, commercially available aromatics in one step.
Original language | English |
---|---|
Number of pages | 5 |
Journal | Organic Letters |
Early online date | 10 May 2018 |
DOIs | |
Publication status | E-pub ahead of print - 10 May 2018 |
Bibliographical note
© 2018 American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for detailsKeywords
- Journal Article
Projects
- 1 Finished
-
Catalytic Asymmetric Dearomative Spirocyclisations
Unsworth, W. P. (Co-investigator)
1/07/15 → 30/06/18
Project: Research project (funded) › Research
Datasets
-
Raw data for the paper 'Dearomatizing Spiroannulation Reagents: Direct Access to Spirocycles from Indoles and Dihalides'
Unsworth, W. P. (Creator), University of York, 2018
DOI: 10.15124/f2f2133b-e404-46c0-a901-bacbb1d4b1ac
Dataset