By the same authors

From the same journal

Deep brain stimulation for chronic pain investigated with magnetoencephalography

Research output: Contribution to journalArticle


  • Morten L. Kringelbach
  • Ned Jenkinson
  • Alexander L. Green
  • Sarah L. F. Owen
  • Peter C. Hansen
  • Piers L. Cornelissen
  • Ian E. Holliday
  • John Stein
  • Tipu Z. Aziz


Publication details

DatePublished - 12 Feb 2007
Issue number3
Number of pages6
Pages (from-to)223-228
Original languageEnglish


Deep brain stimulation has shown remarkable potential in alleviating otherwise treatment-resistant chronic pain, but little is currently known about the underlying neural mechanisms. Here for the first time, we used noninvasive neuroimaging by magnetoencephalography to map changes in neural activity induced by deep brain stimulation in a patient with severe phantom limb pain. When the stimulator was turned off, the patient reported significant increases in subjective pain. Corresponding significant changes in neural activity were found in a network including the mid-anterior orbito-frontal and subgenual cingulate cortices; these areas are known to be involved in pain relief. Hence, they could potentially serve as future surgical targets to relieve chronic pain.

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations