A one-step method for the conversion of nitroarenes into phenols under operationally simple, transition-metal-free conditions is described. This denitrative functionalization protocol provides a concise and economical alternative to conventional three-step synthetic sequences. Experimental and computational studies suggest that nitroarenes may be substituted by an electron-catalysed radical-nucleophilic substitution (SRN1) chain mechanism.
Bibliographical noteFunding Information:
The authors would like to thank the University of York, the University of Manchester, the Leverhulme Trust (for an Early Career Fellowship, ECF‐2019‐135, M.J.J.) and the Royal Society (Research Grant RGS\R1\201268) for financial support. We would also like to thank Dr Jason Lynam, Dr William Unsworth and Prof. Peter O'Brien for helpful discussions.
© 2023 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.
- denitrative functionalisation
- radical anion