Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)

Douglas S. Williamson; Garrick P. Smith; Pamela Acheson-Dossang; Simon T. Bedford; Victoria Chell; I-Jen Chen; Justus C. A. Daechsel; Zoe Daniels; Laurent David; Pawel Dokurno; Morten Hentzer; Martin C. Herzig; Roderick E. Hubbard; Jonathan D. Moore; James B. Murray; Samantha Newland; Stuart C. Ray; Terry Shaw; Allan E. Surgenor; Lindsey Terry; Kenneth Thirstrup; Yikang Wang; Kenneth V. Christensen

doi:10.1021/acs.jmedchem.7b01186

Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)

Douglas S. Williamson, Garrick P. Smith, Pamela Acheson-Dossang, Simon T. Bedford, Victoria Chell, I-Jen Chen, Justus C. A. Daechsel, Zoe Daniels, Laurent David, Pawel Dokurno, Morten Hentzer, Martin C. Herzig, Roderick E. Hubbard, Jonathan D. Moore, James B. Murray, Samantha Newland, Stuart C. Ray, Terry Shaw, Allan E. Surgenor, Lindsey TerryKenneth Thirstrup, Yikang Wang, Kenneth V. Christensen

Chemistry

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	8945-8962
Number of pages	18
Journal	JOURNAL OF MEDICINAL CHEMISTRY
Volume	60
Issue number	21
DOIs	https://doi.org/10.1021/acs.jmedchem.7b01186
Publication status	Published - 12 Oct 2017

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© 2017 American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

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Cite this

Williamson, D. S., Smith, G. P., Acheson-Dossang, P., Bedford, S. T., Chell, V., Chen, I.-J., Daechsel, J. C. A., Daniels, Z., David, L., Dokurno, P., Hentzer, M., Herzig, M. C., Hubbard, R. E., Moore, J. D., Murray, J. B., Newland, S., Ray, S. C., Shaw, T., Surgenor, A. E., ... Christensen, K. V. (2017). Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1). JOURNAL OF MEDICINAL CHEMISTRY, 60(21), 8945-8962. https://doi.org/10.1021/acs.jmedchem.7b01186

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title = "Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)",

author = "Williamson, {Douglas S.} and Smith, {Garrick P.} and Pamela Acheson-Dossang and Bedford, {Simon T.} and Victoria Chell and I-Jen Chen and Daechsel, {Justus C. A.} and Zoe Daniels and Laurent David and Pawel Dokurno and Morten Hentzer and Herzig, {Martin C.} and Hubbard, {Roderick E.} and Moore, {Jonathan D.} and Murray, {James B.} and Samantha Newland and Ray, {Stuart C.} and Terry Shaw and Surgenor, {Allan E.} and Lindsey Terry and Kenneth Thirstrup and Yikang Wang and Christensen, {Kenneth V.}",

note = "{\textcopyright} 2017 American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher{\textquoteright}s self-archiving policy. Further copying may not be permitted; contact the publisher for details",

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Williamson, DS, Smith, GP, Acheson-Dossang, P, Bedford, ST, Chell, V, Chen, I-J, Daechsel, JCA, Daniels, Z, David, L, Dokurno, P, Hentzer, M, Herzig, MC, Hubbard, RE, Moore, JD, Murray, JB, Newland, S, Ray, SC, Shaw, T, Surgenor, AE, Terry, L, Thirstrup, K, Wang, Y & Christensen, KV 2017, 'Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)', JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 21, pp. 8945-8962. https://doi.org/10.1021/acs.jmedchem.7b01186

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T1 - Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)

AU - Williamson, Douglas S.

AU - Smith, Garrick P.

AU - Acheson-Dossang, Pamela

AU - Bedford, Simon T.

AU - Chell, Victoria

AU - Chen, I-Jen

AU - Daechsel, Justus C. A.

AU - Daniels, Zoe

AU - David, Laurent

AU - Dokurno, Pawel

AU - Hentzer, Morten

AU - Herzig, Martin C.

AU - Hubbard, Roderick E.

AU - Moore, Jonathan D.

AU - Murray, James B.

AU - Newland, Samantha

AU - Ray, Stuart C.

AU - Shaw, Terry

AU - Surgenor, Allan E.

AU - Terry, Lindsey

AU - Thirstrup, Kenneth

AU - Wang, Yikang

AU - Christensen, Kenneth V.

N1 - © 2017 American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

PY - 2017/10/12

Y1 - 2017/10/12

U2 - 10.1021/acs.jmedchem.7b01186

DO - 10.1021/acs.jmedchem.7b01186

M3 - Article

SN - 0022-2623

VL - 60

SP - 8945

EP - 8962

JO - JOURNAL OF MEDICINAL CHEMISTRY

JF - JOURNAL OF MEDICINAL CHEMISTRY

IS - 21

ER -