Designing renewable, high-performance solvents with improved toxicity profiles

James Sherwood, Harrie E. Buist, Bart van der Burg, Fergal P. Byrne, Jason E. Camp, Thomas J. Farmer, E. Dinant Kroese, Marie Y. Meima, David Méndez Sevillano, Ángel Puente, Barbara M.A. van Vugt-Lussenburg, James H. Clark*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The ReSolve project brought together expertise from chemistry, engineering, toxicology, techno-economics, and life cycle assessment in order to develop safer, bio-based solvents. This article summarizes findings from the project including the further development of Cyrene™ and 2,2,5,5-tetramethyloxolane (TMO) as replacements for N-methylpyrrolidone (NMP) and toluene, respectively.

Original languageEnglish
Pages (from-to)57-67
Number of pages11
JournalAldrichimica Acta
Issue number2
Publication statusPublished - 2020

Bibliographical note

Funding Information:
This project has received funding from the Bio-Based Industries Joint Undertaking (JU) under the European Union’s Horizon 2020 research and innovation programme under agreement No 745450. This article reflects only the authors’ views and the JU is not responsible for any use that may be made of the information it contains.

Publisher Copyright:
© 2020, Aldrich. All rights reserved.


  • Bio-based
  • Bioassay
  • Cyrene™
  • Extraction
  • Polarity
  • Polymerization
  • Solvent
  • Synthesis
  • Tetramethyloxolane

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