Detection of picomole amounts of biological substrates by para-hydrogen-enhanced NMR methods in conjunction with a suitable receptor complex

Nicholas J. Wood; James A. Brannigan; Simon B. Duckett; Sarah L. Heath; Jane Wagstafft

doi:10.1021/ja074286k

Detection of picomole amounts of biological substrates by para-hydrogen-enhanced NMR methods in conjunction with a suitable receptor complex

Nicholas J. Wood, James A. Brannigan, Simon B. Duckett, Sarah L. Heath, Jane Wagstafft

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

NMR monitoring of solutions containing para -hydrogen and an iridium-based reporter complex is shown to allow the detection of picomole quantities of biological substrates containing suitable donor sites.

Original language	English
Pages (from-to)	11012-+
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	129
Issue number	36
DOIs	https://doi.org/10.1021/ja074286k
Publication status	Published - 12 Sept 2007

Keywords

PARAHYDROGEN INDUCED POLARIZATION
NUCLEOBASES
REACTIVITY
CISPLATIN
ADENINE

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10.1021/ja074286k

Basic Technology: Hyperpolarised technologies for medical and materials sciences
Duckett, S. B. (Principal investigator)
EPSRC
1/11/03 → 31/10/06
Project: Research project (funded) › Research

Cite this

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title = "Detection of picomole amounts of biological substrates by para-hydrogen-enhanced NMR methods in conjunction with a suitable receptor complex",

abstract = "NMR monitoring of solutions containing para -hydrogen and an iridium-based reporter complex is shown to allow the detection of picomole quantities of biological substrates containing suitable donor sites.",

keywords = "PARAHYDROGEN INDUCED POLARIZATION, NUCLEOBASES, REACTIVITY, CISPLATIN, ADENINE",

author = "Wood, {Nicholas J.} and Brannigan, {James A.} and Duckett, {Simon B.} and Heath, {Sarah L.} and Jane Wagstafft",

year = "2007",

month = sep,

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doi = "10.1021/ja074286k",

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journal = "Journal of the American Chemical Society",

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AU - Wood, Nicholas J.

AU - Brannigan, James A.

AU - Duckett, Simon B.

AU - Heath, Sarah L.

AU - Wagstafft, Jane

PY - 2007/9/12

Y1 - 2007/9/12

N2 - NMR monitoring of solutions containing para -hydrogen and an iridium-based reporter complex is shown to allow the detection of picomole quantities of biological substrates containing suitable donor sites.

AB - NMR monitoring of solutions containing para -hydrogen and an iridium-based reporter complex is shown to allow the detection of picomole quantities of biological substrates containing suitable donor sites.

KW - PARAHYDROGEN INDUCED POLARIZATION

KW - NUCLEOBASES

KW - REACTIVITY

KW - CISPLATIN

KW - ADENINE

U2 - 10.1021/ja074286k

DO - 10.1021/ja074286k

M3 - Article

SN - 0002-7863

VL - 129

SP - 11012-+

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 36

ER -

Detection of picomole amounts of biological substrates by para-hydrogen-enhanced NMR methods in conjunction with a suitable receptor complex

Abstract

Keywords

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Projects

Basic Technology: Hyperpolarised technologies for medical and materials sciences

Cite this