Determinants of depression in patients with comorbid depression following cardiac rehabilitation

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Background A prior history of depression, at the point
patients start cardiac rehabilitation (CR), is associated
with poor outcomes; however, little is known about which
factors play a part in determining the extent of benefit
following CR. Therefore, we aim to identify and evaluate
determinants of CR depression outcomes in patients with
comorbid depression.
Methods An observational study of routine practice using
the British Heart Foundation National Audit of Cardiac
Rehabilitation data between April 2012 and March 2017.
Baseline characteristics were examined with independent
samples t-test and χ2
test. A binary logistic regression was
used to predict change in depression outcome following
Results The analysis included 2715 CR participants with
depression history. The determinants of Hospital Anxiety
and Depression Scale (HADS) depression measurement
post-CR were higher total number of comorbidities (OR
0.914, 95%CI 0.854 to 0.979), a higher HADS anxiety
score (OR 0.883, 95%CI 0.851 to 0.917), physical
inactivity (OR 0.707, 95%CI 0.514 to 0.971), not-smoking
at baseline (OR 1.774, 95%CI 1.086 to 2.898) and male
gender (OR 0.721, 95%CI 0.523 to 0.992).
Conclusion Baseline characteristics of patients with
comorbid depression such as higher anxiety, higher total
number of comorbidities, smoking, physical inactivity
and male gender were predictors of their depression
levels following CR. CR programmes need to be aware
of comorbid depression and these related patient
characteristics associated with better CR outcomes.
Original languageEnglish
Number of pages6
JournalOpen Heart
Issue number1
Publication statusPublished - 9 Apr 2019

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