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Determination of nicotine and N-nitrosamines in house dust by pressurized liquid extraction and comprehensive gas chromatography-Nitrogen chemiluminiscence detection

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JournalJournal of Chromatography A
DatePublished - 6 Jan 2012
Number of pages8
Pages (from-to)180-187
Original languageEnglish


A novel, highly selective method for the determination of nicotine. N-nitrosamines and tobacco-specific nitrosamines (TSNAs) in indoor dust samples is presented in this study. Samples were extracted by in-cell clean-up pressurized liquid extraction (PLE) that allows high extraction efficiency with moderate consumption of organic solvents. The extracts were analyzed by comprehensive gas chromatography and detected with a nitrogen chemiluminiscence detector (GC x GC-NCD) that provided enhanced selectivity and sensitivity for organic nitrogen containing compounds. Method validation showed good linearity, repeatability and reproducibility (%RSD < 8%). Recovery was higher than 80% for most target compounds and limits of detection lower than 16 ng g(-1). The method was used for the determination of the nitrosamine target compounds in house dust samples from both smoking and non-smoking households. All the analytes were found in the samples, nicotine being the most abundant compound in smokers' dust and one of the most abundant in non-smokers' dust. To our knowledge this is the first time that volatile N-nitrosamines and TSNAs have been determined in indoor dust samples. The results demonstrate the presence of these highly carcinogenic compounds in house dust, with inherent human exposure through inhalation and/or involuntary ingestion of house dust. (C) 2011 Elsevier B.V. All rights reserved.

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