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Development of pharmaceutically relevant bio-based intermediates though aldol condensation and Claisen-Schmidt reactions of dihydrolevoglucosenone (Cyrene®)

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JournalGreen Chemistry
DateAccepted/In press - 23 May 2018
DatePublished (current) - 25 May 2018
Number of pages6
Pages (from-to)1-6
Original languageEnglish


Dihydrolevoglucosenone (Cyrene®) has been successfully utilised as a bio-based platform molecule for the synthesis of pharmaceutically relevant intermediates through aldol condensation reactions. Utilising sustainable synthetic methodologies, the self-aldol condensations reaction of Cyrene was achieved in high purity, with isolated yields of 81.3%. Claisen-Schmidt reactions with a range of aromatic and heteroaromatic aldehydes yielded novel cyrene-based compounds, characterised by single-crystal X-ray diffraction, FT-IR, NMR and MS.

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© The Royal Society of Chemistry 2018. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

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