Development of Tunable Mechanism-Based Carbasugar Ligands that Stabilize Glycoside Hydrolases through the Formation of Transient Covalent Intermediates

Sandeep Bhosale; Sachin Kandalkar; Pierre-André Gilormini; Oluwafemi Akintola; Rhianna J Rowland; Pal John Pal Adabala; Dustin King; Matthew C. Deen; Kelly Xi; Gideon J. Davies; David J. Vocadlo; Andrew J. Bennet

doi:10.1021/acscatal.4c04549

Development of Tunable Mechanism-Based Carbasugar Ligands that Stabilize Glycoside Hydrolases through the Formation of Transient Covalent Intermediates

Sandeep Bhosale, Sachin Kandalkar, Pierre-André Gilormini, Oluwafemi Akintola, Rhianna J Rowland, Pal John Pal Adabala, Dustin King, Matthew C. Deen, Kelly Xi, Gideon J. Davies, David J. Vocadlo, Andrew J. Bennet

Chemistry

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	14769−14779
Number of pages	11
Journal	ACS Catalysis
Volume	14
Issue number	19
DOIs	https://doi.org/10.1021/acscatal.4c04549
Publication status	Published - 20 Sept 2024

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10.1021/acscatal.4c04549Licence: CC BY-NC-ND

Development of Tunable Mechanism-Based Carbasugar Ligandsthat Stabilize Glycoside Hydrolases through the Formation ofTransient Covalent Intermediates
© 2024 The Authors.
Final published version, 2.72 MBLicence: CC BY-NC-ND

1 Finished
1 Active

RS Research Professorship
Davies, G. J. (Principal investigator)
THE ROYAL SOCIETY
1/01/17 → 31/12/26
Project: Research project (funded) › Research
X-ray Diffraction Equipment for Macromolecular Crystallography at York
Davies, G. J. (Principal investigator), Antson, A. A. (Co-investigator), Brzozowski, A. M. (Co-investigator), Cowtan, K. (Co-investigator), Fascione, M. A. (Co-investigator), Grogan, G. J. (Co-investigator), Plevin, M. J. (Co-investigator), Thomas, G. H. (Co-investigator), Wilkinson, A. J. (Co-investigator), Willems, L. I. (Co-investigator) & Wilson, K. S. (Co-investigator)
BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL)
18/09/20 → 17/09/22
Project: Research project (funded) › Research

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Bhosale, S., Kandalkar, S., Gilormini, P.-A., Akintola, O., Rowland, R. J., Adabala, P. J. P., King, D., Deen, M. C., Xi, K., Davies, G. J., Vocadlo, D. J., & Bennet, A. J. (2024). Development of Tunable Mechanism-Based Carbasugar Ligands that Stabilize Glycoside Hydrolases through the Formation of Transient Covalent Intermediates. ACS Catalysis, 14(19), 14769−14779. https://doi.org/10.1021/acscatal.4c04549

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title = "Development of Tunable Mechanism-Based Carbasugar Ligands that Stabilize Glycoside Hydrolases through the Formation of Transient Covalent Intermediates",

author = "Sandeep Bhosale and Sachin Kandalkar and Pierre-Andr{\'e} Gilormini and Oluwafemi Akintola and Rowland, {Rhianna J} and Adabala, {Pal John Pal} and Dustin King and Deen, {Matthew C.} and Kelly Xi and Davies, {Gideon J.} and Vocadlo, {David J.} and Bennet, {Andrew J.}",

note = "{\textcopyright} 2024 The Authors.",

year = "2024",

month = sep,

day = "20",

doi = "10.1021/acscatal.4c04549",

language = "English",

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pages = "14769−14779",

journal = "ACS Catalysis",

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Bhosale, S, Kandalkar, S, Gilormini, P-A, Akintola, O, Rowland, RJ, Adabala, PJP, King, D, Deen, MC, Xi, K, Davies, GJ, Vocadlo, DJ & Bennet, AJ 2024, 'Development of Tunable Mechanism-Based Carbasugar Ligands that Stabilize Glycoside Hydrolases through the Formation of Transient Covalent Intermediates', ACS Catalysis, vol. 14, no. 19, pp. 14769−14779. https://doi.org/10.1021/acscatal.4c04549

TY - JOUR

T1 - Development of Tunable Mechanism-Based Carbasugar Ligands that Stabilize Glycoside Hydrolases through the Formation of Transient Covalent Intermediates

AU - Bhosale, Sandeep

AU - Kandalkar, Sachin

AU - Gilormini, Pierre-André

AU - Akintola, Oluwafemi

AU - Rowland, Rhianna J

AU - Adabala, Pal John Pal

AU - King, Dustin

AU - Deen, Matthew C.

AU - Xi, Kelly

AU - Davies, Gideon J.

AU - Vocadlo, David J.

AU - Bennet, Andrew J.

PY - 2024/9/20

Y1 - 2024/9/20

U2 - 10.1021/acscatal.4c04549

DO - 10.1021/acscatal.4c04549

M3 - Article

SN - 2155-5435

VL - 14

SP - 14769−14779

JO - ACS Catalysis

JF - ACS Catalysis

IS - 19

ER -

Development of Tunable Mechanism-Based Carbasugar Ligands that Stabilize Glycoside Hydrolases through the Formation of Transient Covalent Intermediates

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Projects

RS Research Professorship

X-ray Diffraction Equipment for Macromolecular Crystallography at York

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