Developmental differentiation in Leishmania lifecycle progression: post-transcriptional control conducts the orchestra

Luis Miguel De Pablos Torro; Tiago R. Ferreira; Pegine Bavonne Walrad

doi:10.1016/j.mib.2016.08.004

Developmental differentiation in Leishmania lifecycle progression: post-transcriptional control conducts the orchestra

Luis Miguel De Pablos Torro, Tiago R. Ferreira, Pegine Bavonne Walrad

Research output: Contribution to journal › Article › peer-review

Abstract

The successful progression of Leishmania spp. through their lifecycle entails a series of differentiation processes; the proliferative procyclic promastigote forms become quiescent, human-infective metacyclic promastigotes during metacyclogenesis in the sandfly vector, which then differentiate into amastigotes during amastigogenesis in the mammalian host. The progression to these infective forms requires two components: environmental cues and a coordinated cellular response. Recent studies have shown that the Leishmania cellular transformation into mammalian-infective stages is triggered by broad changes in the absolute and relative RNA and protein levels. In this review, we will discuss the implications of Leishmania transcriptomic and proteomic fluctuations, which adapt the parasitic cell for survival.

Original language	English
Pages (from-to)	82-89
Journal	Current Opinion in Microbiology
Volume	34
Early online date	9 Sept 2016
DOIs	https://doi.org/10.1016/j.mib.2016.08.004
Publication status	Published - Dec 2016

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10.1016/j.mib.2016.08.004

http://www.sciencedirect.com/science/article/pii/S1369527416301217

Cite this

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title = "Developmental differentiation in Leishmania lifecycle progression: post-transcriptional control conducts the orchestra",

abstract = "The successful progression of Leishmania spp. through their lifecycle entails a series of differentiation processes; the proliferative procyclic promastigote forms become quiescent, human-infective metacyclic promastigotes during metacyclogenesis in the sandfly vector, which then differentiate into amastigotes during amastigogenesis in the mammalian host. The progression to these infective forms requires two components: environmental cues and a coordinated cellular response. Recent studies have shown that the Leishmania cellular transformation into mammalian-infective stages is triggered by broad changes in the absolute and relative RNA and protein levels. In this review, we will discuss the implications of Leishmania transcriptomic and proteomic fluctuations, which adapt the parasitic cell for survival.",

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