Developmental differentiation in Leishmania lifecycle progression: post-transcriptional control conducts the orchestra

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JournalCurrent Opinion in Microbiology
DateAccepted/In press - 3 Aug 2016
DateE-pub ahead of print - 9 Sep 2016
DatePublished (current) - Dec 2016
Volume34
Pages (from-to)82-89
Early online date9/09/16
Original languageEnglish

Abstract

The successful progression of Leishmania spp. through their lifecycle entails a series of differentiation processes; the proliferative procyclic promastigote forms become quiescent, human-infective metacyclic promastigotes during metacyclogenesis in the sandfly vector, which then differentiate into amastigotes during amastigogenesis in the mammalian host. The progression to these infective forms requires two components: environmental cues and a coordinated cellular response. Recent studies have shown that the Leishmania cellular transformation into mammalian-infective stages is triggered by broad changes in the absolute and relative RNA and protein levels. In this review, we will discuss the implications of Leishmania transcriptomic and proteomic fluctuations, which adapt the parasitic cell for survival.

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