Diagnosis, prognostic factors, and assessment of ALL in adults: 2024 ELN recommendations from a European expert panel

Nicola Gökbuget; Nicolas Boissel; Sabina Chiaretti; Hervé Dombret; Michael Doubek; Adele Fielding; Robin Foà; Sebastian Giebel; Dieter Hoelzer; Mathilde Hunault; David I Marks; Giovanni Martinelli; Oliver Ottmann; Anita Rijneveld; Philippe Rousselot; Josep Ribera; Renato Bassan

doi:10.1182/blood.2023020794

Diagnosis, prognostic factors, and assessment of ALL in adults: 2024 ELN recommendations from a European expert panel

Nicola Gökbuget, Nicolas Boissel, Sabina Chiaretti, Hervé Dombret, Michael Doubek, Adele Fielding, Robin Foà, Sebastian Giebel, Dieter Hoelzer, Mathilde Hunault, David I Marks, Giovanni Martinelli, Oliver Ottmann, Anita Rijneveld, Philippe Rousselot, Josep Ribera, Renato Bassan

The Hull York Medical School

Research output: Contribution to journal › Review article › peer-review

Abstract

Working groups of the European LeukemiaNet have published several important consensus guidelines. Acute lymphoblastic leukemia (ALL) has many different clinical and biological subgroups and the knowledge on disease biology and therapeutic options is increasing exponentially. The European Working Group for Adult ALL has therefore summarized the current state of the art and provided comprehensive consensus recommendations for diagnostic approaches, biologic and clinical characterization, prognostic factors, and risk stratification as well as definitions of endpoints and outcomes. Aspects of treatment, management of subgroups and specific situations, aftercare, and supportive care are covered in a separate publication. The present recommendation intends to provide guidance for the initial management of adult patients with ALL and to define principles as a basis for future collaborative research.

Original language	English
Pages (from-to)	1891-1902
Number of pages	12
Journal	Blood
Volume	143
Issue number	19
Early online date	31 Jan 2024
DOIs	https://doi.org/10.1182/blood.2023020794
Publication status	Published - 9 May 2024

Bibliographical note

Keywords

Humans
Prognosis
Adult
Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis
Europe

Access to Document

10.1182/blood.2023020794

Cite this

Gökbuget, N., Boissel, N., Chiaretti, S., Dombret, H., Doubek, M., Fielding, A., Foà, R., Giebel, S., Hoelzer, D., Hunault, M., Marks, D. I., Martinelli, G., Ottmann, O., Rijneveld, A., Rousselot, P., Ribera, J., & Bassan, R. (2024). Diagnosis, prognostic factors, and assessment of ALL in adults: 2024 ELN recommendations from a European expert panel. Blood, 143(19), 1891-1902. https://doi.org/10.1182/blood.2023020794

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title = "Diagnosis, prognostic factors, and assessment of ALL in adults: 2024 ELN recommendations from a European expert panel",

abstract = "Working groups of the European LeukemiaNet have published several important consensus guidelines. Acute lymphoblastic leukemia (ALL) has many different clinical and biological subgroups and the knowledge on disease biology and therapeutic options is increasing exponentially. The European Working Group for Adult ALL has therefore summarized the current state of the art and provided comprehensive consensus recommendations for diagnostic approaches, biologic and clinical characterization, prognostic factors, and risk stratification as well as definitions of endpoints and outcomes. Aspects of treatment, management of subgroups and specific situations, aftercare, and supportive care are covered in a separate publication. The present recommendation intends to provide guidance for the initial management of adult patients with ALL and to define principles as a basis for future collaborative research.",

keywords = "Humans, Prognosis, Adult, Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis, Europe",

author = "Nicola G{\"o}kbuget and Nicolas Boissel and Sabina Chiaretti and Herv{\'e} Dombret and Michael Doubek and Adele Fielding and Robin Fo{\`a} and Sebastian Giebel and Dieter Hoelzer and Mathilde Hunault and Marks, {David I} and Giovanni Martinelli and Oliver Ottmann and Anita Rijneveld and Philippe Rousselot and Josep Ribera and Renato Bassan",

note = "{\textcopyright} 2024 American Society of Hematology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.",

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Gökbuget, N, Boissel, N, Chiaretti, S, Dombret, H, Doubek, M, Fielding, A, Foà, R, Giebel, S, Hoelzer, D, Hunault, M, Marks, DI, Martinelli, G, Ottmann, O, Rijneveld, A, Rousselot, P, Ribera, J & Bassan, R 2024, 'Diagnosis, prognostic factors, and assessment of ALL in adults: 2024 ELN recommendations from a European expert panel', Blood, vol. 143, no. 19, pp. 1891-1902. https://doi.org/10.1182/blood.2023020794

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T1 - Diagnosis, prognostic factors, and assessment of ALL in adults

T2 - 2024 ELN recommendations from a European expert panel

AU - Gökbuget, Nicola

AU - Boissel, Nicolas

AU - Chiaretti, Sabina

AU - Dombret, Hervé

AU - Doubek, Michael

AU - Fielding, Adele

AU - Foà, Robin

AU - Giebel, Sebastian

AU - Hoelzer, Dieter

AU - Hunault, Mathilde

AU - Marks, David I

AU - Martinelli, Giovanni

AU - Ottmann, Oliver

AU - Rijneveld, Anita

AU - Rousselot, Philippe

AU - Ribera, Josep

AU - Bassan, Renato

PY - 2024/5/9

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N2 - Working groups of the European LeukemiaNet have published several important consensus guidelines. Acute lymphoblastic leukemia (ALL) has many different clinical and biological subgroups and the knowledge on disease biology and therapeutic options is increasing exponentially. The European Working Group for Adult ALL has therefore summarized the current state of the art and provided comprehensive consensus recommendations for diagnostic approaches, biologic and clinical characterization, prognostic factors, and risk stratification as well as definitions of endpoints and outcomes. Aspects of treatment, management of subgroups and specific situations, aftercare, and supportive care are covered in a separate publication. The present recommendation intends to provide guidance for the initial management of adult patients with ALL and to define principles as a basis for future collaborative research.

AB - Working groups of the European LeukemiaNet have published several important consensus guidelines. Acute lymphoblastic leukemia (ALL) has many different clinical and biological subgroups and the knowledge on disease biology and therapeutic options is increasing exponentially. The European Working Group for Adult ALL has therefore summarized the current state of the art and provided comprehensive consensus recommendations for diagnostic approaches, biologic and clinical characterization, prognostic factors, and risk stratification as well as definitions of endpoints and outcomes. Aspects of treatment, management of subgroups and specific situations, aftercare, and supportive care are covered in a separate publication. The present recommendation intends to provide guidance for the initial management of adult patients with ALL and to define principles as a basis for future collaborative research.

KW - Humans

KW - Prognosis

KW - Adult

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis

KW - Europe

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DO - 10.1182/blood.2023020794

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SN - 0006-4971

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SP - 1891

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JO - Blood

JF - Blood

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