Diastereoselective hydroxylation and reduction of derivatised tetrahydrofurans by Beauveria bassiana

G Grogan, J T Sime, N J Turner

Research output: Contribution to journalArticlepeer-review

Abstract

The filamentous fungus, Beauveria bassiana ATCC 7159, catalyses the regio- and diastereoselective biohydroxylation of trans-2-methyl-5-benzyloxymethyl-tetrahydrofuran to the cis-3-hydroxy derivative. When incubated with cis-2-methyl-3-keto-5-benzyloxymethyltetrahydrofuran, the same fungus performs a reduction to give the cis- and trans-alcohols in a 4:1 ratio.

Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalBIOTECHNOLOGY LETTERS
Volume23
Issue number2
Publication statusPublished - Jan 2001

Keywords

  • Beauveria bassiana
  • biotransformation
  • hydroxylation

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