TY - JOUR
T1 - Differential relational memory impairment in temporal lobe epilepsy
AU - Tavakol, Shahin
AU - Kebets, Valeria
AU - Royer, Jessica
AU - Li, Qiongling
AU - Auer, Hans
AU - DeKraker, Jordan
AU - Jefferies, Elizabeth
AU - Bernasconi, Neda
AU - Bernasconi, Andrea
AU - Helmstaedter, Christoph
AU - Arafat, Thaera
AU - Armony, Jorge
AU - Nathan Spreng, R.
AU - Caciagli, Lorenzo
AU - Frauscher, Birgit
AU - Smallwood, Jonathan
AU - Bernhardt, Boris
N1 - Publisher Copyright:
© 2024
PY - 2024/6
Y1 - 2024/6
N2 - Objective: Temporal lobe epilepsy (TLE) is typically associated with pathology of the hippocampus, a key structure involved in relational memory, including episodic, semantic, and spatial memory processes. While it is widely accepted that TLE-associated hippocampal alterations underlie memory deficits, it remains unclear whether impairments relate to a specific cognitive domain or multiple ones. Methods: We administered a recently validated task paradigm to evaluate episodic, semantic, and spatial memory in 24 pharmacoresistant TLE patients and 50 age- and sex-matched healthy controls. We carried out two-way analyses of variance to identify memory deficits in individuals with TLE relative to controls across different relational memory domains, and used partial least squares correlation to identify factors contributing to variations in relational memory performance across both cohorts. Results: Compared to controls, TLE patients showed marked impairments in episodic and spatial memory, with mixed findings in semantic memory. Even when additionally controlling for age, sex, and overall cognitive function, between-group differences persisted along episodic and spatial domains. Moreover, age, diagnostic group, and hippocampal volume were all associated with relational memory behavioral phenotypes. Significance: Our behavioral findings show graded deficits across relational memory domains in people with TLE, which provides further insights into the complex pattern of cognitive impairment in the condition.
AB - Objective: Temporal lobe epilepsy (TLE) is typically associated with pathology of the hippocampus, a key structure involved in relational memory, including episodic, semantic, and spatial memory processes. While it is widely accepted that TLE-associated hippocampal alterations underlie memory deficits, it remains unclear whether impairments relate to a specific cognitive domain or multiple ones. Methods: We administered a recently validated task paradigm to evaluate episodic, semantic, and spatial memory in 24 pharmacoresistant TLE patients and 50 age- and sex-matched healthy controls. We carried out two-way analyses of variance to identify memory deficits in individuals with TLE relative to controls across different relational memory domains, and used partial least squares correlation to identify factors contributing to variations in relational memory performance across both cohorts. Results: Compared to controls, TLE patients showed marked impairments in episodic and spatial memory, with mixed findings in semantic memory. Even when additionally controlling for age, sex, and overall cognitive function, between-group differences persisted along episodic and spatial domains. Moreover, age, diagnostic group, and hippocampal volume were all associated with relational memory behavioral phenotypes. Significance: Our behavioral findings show graded deficits across relational memory domains in people with TLE, which provides further insights into the complex pattern of cognitive impairment in the condition.
KW - Hippocampus
KW - Relational memory
KW - Temporal lobe epilepsy
UR - http://www.scopus.com/inward/record.url?scp=85190899866&partnerID=8YFLogxK
U2 - 10.1016/j.yebeh.2024.109722
DO - 10.1016/j.yebeh.2024.109722
M3 - Article
C2 - 38643660
AN - SCOPUS:85190899866
SN - 1525-5050
VL - 155
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
M1 - 109722
ER -