By the same authors

From the same journal

From the same journal

Direct and Indirect Hyperpolarisation of Amines using Parahydrogen

Research output: Contribution to journalArticle

Standard

Direct and Indirect Hyperpolarisation of Amines using Parahydrogen. / Iali, Wissam; Rayner, Peter John; Alshehri, Adel Mohammed M; Holmes, J; Ruddlesden, Amy Jane; Duckett, Simon.

In: Chemical Science, Vol. 9, No. 15, C8SC00526E, 21.04.2018, p. 3677-3684.

Research output: Contribution to journalArticle

Harvard

Iali, W, Rayner, PJ, Alshehri, AMM, Holmes, J, Ruddlesden, AJ & Duckett, S 2018, 'Direct and Indirect Hyperpolarisation of Amines using Parahydrogen', Chemical Science, vol. 9, no. 15, C8SC00526E, pp. 3677-3684. https://doi.org/10.1039/C8SC00526E

APA

Iali, W., Rayner, P. J., Alshehri, A. M. M., Holmes, J., Ruddlesden, A. J., & Duckett, S. (2018). Direct and Indirect Hyperpolarisation of Amines using Parahydrogen. Chemical Science, 9(15), 3677-3684. [C8SC00526E]. https://doi.org/10.1039/C8SC00526E

Vancouver

Iali W, Rayner PJ, Alshehri AMM, Holmes J, Ruddlesden AJ, Duckett S. Direct and Indirect Hyperpolarisation of Amines using Parahydrogen. Chemical Science. 2018 Apr 21;9(15):3677-3684. C8SC00526E. https://doi.org/10.1039/C8SC00526E

Author

Iali, Wissam ; Rayner, Peter John ; Alshehri, Adel Mohammed M ; Holmes, J ; Ruddlesden, Amy Jane ; Duckett, Simon. / Direct and Indirect Hyperpolarisation of Amines using Parahydrogen. In: Chemical Science. 2018 ; Vol. 9, No. 15. pp. 3677-3684.

Bibtex - Download

@article{9165b310a3fd4552985a905f9812e0ad,
title = "Direct and Indirect Hyperpolarisation of Amines using Parahydrogen",
abstract = "Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) are two widely used techniques for the study of molecules and materials. Hyperpolarisation methods, such as Signal Amplification By Reversible Exchange (SABRE), turn typically weak magnetic resonance responses into strong signals. In this article we detail how it is possible to hyperpolarise the 1H, 13C and 15N nuclei of a range of amines. This involved showing how primary amines form stable but labile complexes of the type [Ir(H)2(IMes)(amine)3]Cl that allow parahydrogen to relay its latent polarisation into the amine. By optimising the temperature and parahydrogen pressure a 1000-fold per proton NH signal gain for deuterated benzylamine is achieved at 9.4 T. Additionally, we show that sterically hindered and electron poor amines that bind poorly to iridium can be hyperpolarised by either employing a co-ligand for complex stabilisation, or harnessing the fact that it is possible to exchange hyperpolarised protons between amines in a mixture, through the recently reported SABRE-RELAY method. These chemical refinements have significant potential to extend the classes of agent that can be hyperpolarised by readily accessible parahydrogen.",
author = "Wissam Iali and Rayner, {Peter John} and Alshehri, {Adel Mohammed M} and J Holmes and Ruddlesden, {Amy Jane} and Simon Duckett",
note = "This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details",
year = "2018",
month = "4",
day = "21",
doi = "10.1039/C8SC00526E",
language = "English",
volume = "9",
pages = "3677--3684",
journal = "Chemical Science",
issn = "2041-6520",
publisher = "The Royal Society of Chemistry",
number = "15",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Direct and Indirect Hyperpolarisation of Amines using Parahydrogen

AU - Iali, Wissam

AU - Rayner, Peter John

AU - Alshehri, Adel Mohammed M

AU - Holmes, J

AU - Ruddlesden, Amy Jane

AU - Duckett, Simon

N1 - This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

PY - 2018/4/21

Y1 - 2018/4/21

N2 - Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) are two widely used techniques for the study of molecules and materials. Hyperpolarisation methods, such as Signal Amplification By Reversible Exchange (SABRE), turn typically weak magnetic resonance responses into strong signals. In this article we detail how it is possible to hyperpolarise the 1H, 13C and 15N nuclei of a range of amines. This involved showing how primary amines form stable but labile complexes of the type [Ir(H)2(IMes)(amine)3]Cl that allow parahydrogen to relay its latent polarisation into the amine. By optimising the temperature and parahydrogen pressure a 1000-fold per proton NH signal gain for deuterated benzylamine is achieved at 9.4 T. Additionally, we show that sterically hindered and electron poor amines that bind poorly to iridium can be hyperpolarised by either employing a co-ligand for complex stabilisation, or harnessing the fact that it is possible to exchange hyperpolarised protons between amines in a mixture, through the recently reported SABRE-RELAY method. These chemical refinements have significant potential to extend the classes of agent that can be hyperpolarised by readily accessible parahydrogen.

AB - Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) are two widely used techniques for the study of molecules and materials. Hyperpolarisation methods, such as Signal Amplification By Reversible Exchange (SABRE), turn typically weak magnetic resonance responses into strong signals. In this article we detail how it is possible to hyperpolarise the 1H, 13C and 15N nuclei of a range of amines. This involved showing how primary amines form stable but labile complexes of the type [Ir(H)2(IMes)(amine)3]Cl that allow parahydrogen to relay its latent polarisation into the amine. By optimising the temperature and parahydrogen pressure a 1000-fold per proton NH signal gain for deuterated benzylamine is achieved at 9.4 T. Additionally, we show that sterically hindered and electron poor amines that bind poorly to iridium can be hyperpolarised by either employing a co-ligand for complex stabilisation, or harnessing the fact that it is possible to exchange hyperpolarised protons between amines in a mixture, through the recently reported SABRE-RELAY method. These chemical refinements have significant potential to extend the classes of agent that can be hyperpolarised by readily accessible parahydrogen.

UR - http://www.scopus.com/inward/record.url?scp=85045729772&partnerID=8YFLogxK

U2 - 10.1039/C8SC00526E

DO - 10.1039/C8SC00526E

M3 - Article

VL - 9

SP - 3677

EP - 3684

JO - Chemical Science

T2 - Chemical Science

JF - Chemical Science

SN - 2041-6520

IS - 15

M1 - C8SC00526E

ER -