Direct enhancement of nitrogen-15 targets at high-field by fast ADAPT-SABRE

Soumya S. Roy; Gabriele Stevanato; Peter J. Rayner; Simon B. Duckett

doi:10.1016/j.jmr.2017.10.006

Direct enhancement of nitrogen-15 targets at high-field by fast ADAPT-SABRE

Soumya S. Roy, Gabriele Stevanato, Peter J. Rayner, Simon B. Duckett^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Signal Amplification by Reversible Exchange (SABRE) is an attractive nuclear spin hyperpolarization technique capable of huge sensitivity enhancement in nuclear magnetic resonance (NMR) detection. The resonance condition of SABRE hyperpolarization depends on coherent spin mixing, which can be achieved naturally at a low magnetic field. The optimum transfer field to spin-1/2 heteronuclei is technically demanding, as it requires field strengths weaker than the earth's magnetic field for efficient spin mixing. In this paper, we illustrate an approach to achieve strong ¹⁵N SABRE hyperpolarization at high magnetic field by a radio frequency (RF) driven coherent transfer mechanism based on alternate pulsing and delay to achieve polarization transfer. The presented scheme is found to be highly robust and much faster than existing related methods, producing ∼3 orders of magnitude ¹⁵N signal enhancement within 2 s of RF pulsing.

Original language	English
Article number	YJMRE6177
Pages (from-to)	55-60
Number of pages	6
Journal	Journal of Magnetic Resonance
Volume	285
Early online date	21 Oct 2017
DOIs	https://doi.org/10.1016/j.jmr.2017.10.006
Publication status	Published - 1 Dec 2017

Keywords

ADAPT
Hyperpolarization
PHIP
SABRE

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10.1016/j.jmr.2017.10.006

JMR-17-254R1Accepted author manuscript, 7.9 MBLicence: CC BY

Cite this

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title = "Direct enhancement of nitrogen-15 targets at high-field by fast ADAPT-SABRE",

abstract = "Signal Amplification by Reversible Exchange (SABRE) is an attractive nuclear spin hyperpolarization technique capable of huge sensitivity enhancement in nuclear magnetic resonance (NMR) detection. The resonance condition of SABRE hyperpolarization depends on coherent spin mixing, which can be achieved naturally at a low magnetic field. The optimum transfer field to spin-1/2 heteronuclei is technically demanding, as it requires field strengths weaker than the earth's magnetic field for efficient spin mixing. In this paper, we illustrate an approach to achieve strong 15N SABRE hyperpolarization at high magnetic field by a radio frequency (RF) driven coherent transfer mechanism based on alternate pulsing and delay to achieve polarization transfer. The presented scheme is found to be highly robust and much faster than existing related methods, producing ∼3 orders of magnitude 15N signal enhancement within 2 s of RF pulsing.",

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AU - Roy, Soumya S.

AU - Stevanato, Gabriele

AU - Rayner, Peter J.

AU - Duckett, Simon B.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Signal Amplification by Reversible Exchange (SABRE) is an attractive nuclear spin hyperpolarization technique capable of huge sensitivity enhancement in nuclear magnetic resonance (NMR) detection. The resonance condition of SABRE hyperpolarization depends on coherent spin mixing, which can be achieved naturally at a low magnetic field. The optimum transfer field to spin-1/2 heteronuclei is technically demanding, as it requires field strengths weaker than the earth's magnetic field for efficient spin mixing. In this paper, we illustrate an approach to achieve strong 15N SABRE hyperpolarization at high magnetic field by a radio frequency (RF) driven coherent transfer mechanism based on alternate pulsing and delay to achieve polarization transfer. The presented scheme is found to be highly robust and much faster than existing related methods, producing ∼3 orders of magnitude 15N signal enhancement within 2 s of RF pulsing.

AB - Signal Amplification by Reversible Exchange (SABRE) is an attractive nuclear spin hyperpolarization technique capable of huge sensitivity enhancement in nuclear magnetic resonance (NMR) detection. The resonance condition of SABRE hyperpolarization depends on coherent spin mixing, which can be achieved naturally at a low magnetic field. The optimum transfer field to spin-1/2 heteronuclei is technically demanding, as it requires field strengths weaker than the earth's magnetic field for efficient spin mixing. In this paper, we illustrate an approach to achieve strong 15N SABRE hyperpolarization at high magnetic field by a radio frequency (RF) driven coherent transfer mechanism based on alternate pulsing and delay to achieve polarization transfer. The presented scheme is found to be highly robust and much faster than existing related methods, producing ∼3 orders of magnitude 15N signal enhancement within 2 s of RF pulsing.

KW - ADAPT

KW - Hyperpolarization

KW - PHIP

KW - SABRE

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M3 - Article

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JO - Journal of Magnetic Resonance

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Direct enhancement of nitrogen-15 targets at high-field by fast ADAPT-SABRE

Abstract

Keywords

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Other files and links

Hyperpolarisation using SABRE as a new tool for imaging