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Direct enhancement of nitrogen-15 targets at high-field by fast ADAPT-SABRE

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Publication details

JournalJournal of Magnetic Resonance
DateAccepted/In press - 14 Oct 2017
DateE-pub ahead of print - 21 Oct 2017
DatePublished (current) - 1 Dec 2017
Number of pages6
Pages (from-to)55-60
Early online date21/10/17
Original languageEnglish


Signal Amplification by Reversible Exchange (SABRE) is an attractive nuclear spin hyperpolarization technique capable of huge sensitivity enhancement in nuclear magnetic resonance (NMR) detection. The resonance condition of SABRE hyperpolarization depends on coherent spin mixing, which can be achieved naturally at a low magnetic field. The optimum transfer field to spin-1/2 heteronuclei is technically demanding, as it requires field strengths weaker than the earth's magnetic field for efficient spin mixing. In this paper, we illustrate an approach to achieve strong 15N SABRE hyperpolarization at high magnetic field by a radio frequency (RF) driven coherent transfer mechanism based on alternate pulsing and delay to achieve polarization transfer. The presented scheme is found to be highly robust and much faster than existing related methods, producing ∼3 orders of magnitude 15N signal enhancement within 2 s of RF pulsing.

    Research areas

  • ADAPT, Hyperpolarization, PHIP, SABRE

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