Direct imine acylation for molecular diversity in heterocyclic synthesis

William Paul Unsworth, Graeme Coulthard, Christiana Kitsiou, Richard John Kenneth Taylor

Research output: Contribution to journalArticlepeer-review


Imines and carboxylic acids have been directly coupled using propylphosphonic acid anhydride and NEt(i-Pr)2 to give N acyliminium ions which were intramolecularly trapped with oxygen, nitrogen, sulfur, and carbon nucleophiles to provide a wide range of structurally diverse heterocycles.

Original languageEnglish
Pages (from-to)1368-1376
Number of pages9
JournalThe Journal of organic chemistry
Issue number3
Early online date17 Jan 2014
Publication statusPublished - 7 Feb 2014

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©2014 American Chemical Society

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