Direct imine acylation for molecular diversity in heterocyclic synthesis

William Paul Unsworth; Graeme Coulthard; Christiana Kitsiou; Richard John Kenneth Taylor

doi:10.1021/jo402768r

Direct imine acylation for molecular diversity in heterocyclic synthesis

William Paul Unsworth, Graeme Coulthard, Christiana Kitsiou, Richard John Kenneth Taylor

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Imines and carboxylic acids have been directly coupled using propylphosphonic acid anhydride and NEt(i-Pr)₂ to give N acyliminium ions which were intramolecularly trapped with oxygen, nitrogen, sulfur, and carbon nucleophiles to provide a wide range of structurally diverse heterocycles.

Original language	English
Pages (from-to)	1368-1376
Number of pages	9
Journal	The Journal of organic chemistry
Volume	79
Issue number	3
Early online date	17 Jan 2014
DOIs	https://doi.org/10.1021/jo402768r
Publication status	Published - 7 Feb 2014

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10.1021/jo402768r

Cite this

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title = "Direct imine acylation for molecular diversity in heterocyclic synthesis",

abstract = "Imines and carboxylic acids have been directly coupled using propylphosphonic acid anhydride and NEt(i-Pr)2 to give N acyliminium ions which were intramolecularly trapped with oxygen, nitrogen, sulfur, and carbon nucleophiles to provide a wide range of structurally diverse heterocycles.",

author = "Unsworth, {William Paul} and Graeme Coulthard and Christiana Kitsiou and Taylor, {Richard John Kenneth}",

note = "{\textcopyright}2014 American Chemical Society",

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AU - Coulthard, Graeme

AU - Kitsiou, Christiana

AU - Taylor, Richard John Kenneth

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AB - Imines and carboxylic acids have been directly coupled using propylphosphonic acid anhydride and NEt(i-Pr)2 to give N acyliminium ions which were intramolecularly trapped with oxygen, nitrogen, sulfur, and carbon nucleophiles to provide a wide range of structurally diverse heterocycles.

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DO - 10.1021/jo402768r

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JO - The Journal of organic chemistry

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