Direct imine acylation: rapid access to diverse heterocyclic scaffolds

Research output: Contribution to journalArticlepeer-review


A simple and efficient procedure to prepare a range of diverse heterocycles by the direct acylation of imines using a variety of functionalized benzoic acids is described. The methodology features a novel method for N-acyliminium ion generation followed by in situ intramolecular trapping by oxygen-, nitrogen-, sulfur- and carbon-based nucleophiles. Preliminary mechanistic studies, using ReactIR, are also reported.
Original languageEnglish
Pages (from-to)258-61
Number of pages4
JournalOrganic Letters
Issue number2
Early online date24 Dec 2012
Publication statusPublished - 18 Jan 2013

Cite this