Direct imine acylation: synthesis of the proposed structures of 'upenamide

William P Unsworth, Katherine A Gallagher, Mickaël Jean, Jan Peter Schmidt, Louis J Diorazio, Richard J K Taylor

Research output: Contribution to journalArticlepeer-review


The synthesis of the two proposed structures of macrocyclic marine natural product 'upenamide is reported. The key step utilizes direct imine acylation (DIA) with a protected β-hydroxy acid to construct the key tricyclic ABC ring system. The macrocyclization was completed in the final step using a Stille cross-coupling reaction.
Original languageEnglish
Pages (from-to)262-5
Number of pages4
JournalOrganic Letters
Issue number2
Early online date24 Dec 2012
Publication statusPublished - 18 Jan 2013

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