Direct imine acylation: synthesis of the proposed structures of 'upenamide

TY - JOUR

T1 - Direct imine acylation

T2 - synthesis of the proposed structures of 'upenamide

AU - Unsworth, William P

AU - Gallagher, Katherine A

AU - Jean, Mickaël

AU - Schmidt, Jan Peter

AU - Diorazio, Louis J

AU - Taylor, Richard J K

PY - 2013/1/18

Y1 - 2013/1/18

N2 - The synthesis of the two proposed structures of macrocyclic marine natural product 'upenamide is reported. The key step utilizes direct imine acylation (DIA) with a protected β-hydroxy acid to construct the key tricyclic ABC ring system. The macrocyclization was completed in the final step using a Stille cross-coupling reaction.

AB - The synthesis of the two proposed structures of macrocyclic marine natural product 'upenamide is reported. The key step utilizes direct imine acylation (DIA) with a protected β-hydroxy acid to construct the key tricyclic ABC ring system. The macrocyclization was completed in the final step using a Stille cross-coupling reaction.

UR - http://www.scopus.com/inward/record.url?scp=84872584882&partnerID=8YFLogxK

U2 - 10.1021/ol3030764

DO - 10.1021/ol3030764

M3 - Article

C2 - 23265326

SN - 1523-7060

VL - 15

SP - 262

EP - 265

JO - Organic Letters

JF - Organic Letters

IS - 2

ER -