Direct Measurement of the Visible to UV Photodissociation Processes for the PhotoCORM TryptoCORM

Caroline Elizabeth Helen Dessent, Rosaria Cercola, Natalie Wong, Jason Martin Lynam, Ian James Stewart Fairlamb, Anders Hammarback, Etienne Garand, Kaitlyn Fischer, Summer Sherman

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PhotoCORMs are light‐triggered compounds that release CO for medical applications. Here, we apply laser spectroscopy in the gas phase to TryptoCORM, a known photoCORM that has been shown to destroy Escherichia coli upon visible‐light activation. Our experiments allow us to map TryptoCORM’s photochemistry across a wide wavelength range by using novel laser‐interfaced mass spectrometry (LIMS). LIMS provides the intrinsic absorption spectrum of the photoCORM along with the production spectra of all of its ionic photoproducts for the first time. Importantly, the photoproduct spectra directly reveal the optimum wavelengths for maximizing CO ejection, and the extent to which CO ejection is compromised at redder wavelengths. A series of comparative studies were performed on TryptoCORM‐CH3CN which exists in dynamic equilibrium with TryptoCORM in solution. Our measurements allow us to conclude that the presence of the labile CH3CN facilitates CO release over a wider wavelength range. This work demonstrates the potential of LIMS as a new methodology for assessing active agent release ( e.g. CO, NO, H2S) from light‐activated prodrugs.
Original languageEnglish
JournalChemistry : A European Journal
Early online date10 Apr 2020
Publication statusE-pub ahead of print - 10 Apr 2020


  • CORM
  • PhotoCORM
  • Laser Photochemistry
  • Antimicrobial
  • transition metal complexes

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