By the same authors

From the same journal

Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase

Research output: Contribution to journalArticle

Published copy (DOI)

Author(s)

Department/unit(s)

Publication details

JournalMedChemComm
DatePublished - 17 Aug 2015
Issue number10
Volume6
Number of pages6
Pages (from-to)1761-1766
Original languageEnglish

Abstract

N-Myristoyltransferase (NMT) is a potential drug target in Leishmania parasites. Scaffold-hopping from published inhibitors yielded the serendipitous discovery of a chemotype selective for Leishmania donovani NMT; development led to high affinity inhibitors with excellent ligand efficiency. The binding mode was characterised by crystallography and provides a structural rationale for selectivity.

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations