Projects per year
Abstract
N-Myristoyltransferase (NMT) is a prospective drug target against parasitic protozoa. Herein we report the successful discovery of a series of Plasmodium vivax NMT inhibitors by high-throughput screening. A high-resolution crystal structure of the hit compound in complex with NMT was obtained, allowing understanding of its novel binding mode. A set of analogues was designed and tested to define the chemical groups relevant for activity and selectivity.
Original language | English |
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Pages (from-to) | 3578-82 |
Number of pages | 5 |
Journal | JOURNAL OF MEDICINAL CHEMISTRY |
Volume | 55 |
Issue number | 7 |
DOIs | |
Publication status | Published - 12 Apr 2012 |
Projects
- 1 Finished
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N-Myristol Transferase as a drug target for anti-malarial therapy
Wilkinson, A. J. (Principal investigator)
MEDICAL RESEARCH COUNCIL (MRC)
1/06/10 → 31/05/14
Project: Research project (funded) › Research