Disrupted autophagy undermines skeletal muscle adaptation and integrity

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Disrupted autophagy undermines skeletal muscle adaptation and integrity. / Jokl, Elliot J; Blanco, Gonzalo.

In: Mammalian genome : official journal of the International Mammalian Genome Society, 02.08.2016.

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Jokl, EJ & Blanco, G 2016, 'Disrupted autophagy undermines skeletal muscle adaptation and integrity', Mammalian genome : official journal of the International Mammalian Genome Society. https://doi.org/10.1007/s00335-016-9659-2

APA

Jokl, E. J., & Blanco, G. (2016). Disrupted autophagy undermines skeletal muscle adaptation and integrity. Mammalian genome : official journal of the International Mammalian Genome Society. https://doi.org/10.1007/s00335-016-9659-2

Vancouver

Jokl EJ, Blanco G. Disrupted autophagy undermines skeletal muscle adaptation and integrity. Mammalian genome : official journal of the International Mammalian Genome Society. 2016 Aug 2. https://doi.org/10.1007/s00335-016-9659-2

Author

Jokl, Elliot J ; Blanco, Gonzalo. / Disrupted autophagy undermines skeletal muscle adaptation and integrity. In: Mammalian genome : official journal of the International Mammalian Genome Society. 2016.

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@article{edb0479b17b3463ab4111afbebc9e48d,
title = "Disrupted autophagy undermines skeletal muscle adaptation and integrity",
abstract = "This review assesses the importance of proteostasis in skeletal muscle maintenance with a specific emphasis on autophagy. Skeletal muscle appears to be particularly vulnerable to genetic defects in basal and induced autophagy, indicating that autophagy is co-substantial to skeletal muscle maintenance and adaptation. We discuss emerging evidence that tension-induced protein unfolding may act as a direct link between mechanical stress and autophagic pathways. Mechanistic links between protein damage, autophagy and muscle hypertrophy, which is also induced by mechanical stress, are still poorly understood. However, some mouse models of muscle disease show ameliorated symptoms upon effective targeting of basal autophagy. These findings highlight the importance of autophagy as therapeutic target and suggest that elucidating connections between protein unfolding and mTOR-dependent or mTOR-independent hypertrophic responses is likely to reveal specific therapeutic windows for the treatment of muscle wasting disorders.",
author = "Jokl, {Elliot J} and Gonzalo Blanco",
note = "{\textcopyright} The Author(s) 2016",
year = "2016",
month = aug,
day = "2",
doi = "10.1007/s00335-016-9659-2",
language = "English",
journal = "Mammalian genome : official journal of the International Mammalian Genome Society",
issn = "0938-8990",
publisher = "Springer New York",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Disrupted autophagy undermines skeletal muscle adaptation and integrity

AU - Jokl, Elliot J

AU - Blanco, Gonzalo

N1 - © The Author(s) 2016

PY - 2016/8/2

Y1 - 2016/8/2

N2 - This review assesses the importance of proteostasis in skeletal muscle maintenance with a specific emphasis on autophagy. Skeletal muscle appears to be particularly vulnerable to genetic defects in basal and induced autophagy, indicating that autophagy is co-substantial to skeletal muscle maintenance and adaptation. We discuss emerging evidence that tension-induced protein unfolding may act as a direct link between mechanical stress and autophagic pathways. Mechanistic links between protein damage, autophagy and muscle hypertrophy, which is also induced by mechanical stress, are still poorly understood. However, some mouse models of muscle disease show ameliorated symptoms upon effective targeting of basal autophagy. These findings highlight the importance of autophagy as therapeutic target and suggest that elucidating connections between protein unfolding and mTOR-dependent or mTOR-independent hypertrophic responses is likely to reveal specific therapeutic windows for the treatment of muscle wasting disorders.

AB - This review assesses the importance of proteostasis in skeletal muscle maintenance with a specific emphasis on autophagy. Skeletal muscle appears to be particularly vulnerable to genetic defects in basal and induced autophagy, indicating that autophagy is co-substantial to skeletal muscle maintenance and adaptation. We discuss emerging evidence that tension-induced protein unfolding may act as a direct link between mechanical stress and autophagic pathways. Mechanistic links between protein damage, autophagy and muscle hypertrophy, which is also induced by mechanical stress, are still poorly understood. However, some mouse models of muscle disease show ameliorated symptoms upon effective targeting of basal autophagy. These findings highlight the importance of autophagy as therapeutic target and suggest that elucidating connections between protein unfolding and mTOR-dependent or mTOR-independent hypertrophic responses is likely to reveal specific therapeutic windows for the treatment of muscle wasting disorders.

U2 - 10.1007/s00335-016-9659-2

DO - 10.1007/s00335-016-9659-2

M3 - Article

C2 - 27484057

JO - Mammalian genome : official journal of the International Mammalian Genome Society

JF - Mammalian genome : official journal of the International Mammalian Genome Society

SN - 0938-8990

ER -