Distinguishing functions of trypanosomatid protein kinases

Mathieu Cayla; Y. Romina Nievas; Keith R. Matthews; Jeremy C. Mottram

doi:10.1016/j.pt.2022.08.009

Distinguishing functions of trypanosomatid protein kinases

Mathieu Cayla, Y. Romina Nievas, Keith R. Matthews, Jeremy C. Mottram

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Trypanosomatid parasitic protozoa are divergent from opisthokont models and have evolved unique mechanisms to regulate their complex life cycles and to adapt to a range of hosts. Understanding how these organisms respond, adapt, and persist in their different hosts could reveal optimal drug-control strategies. Protein kinases are fundamental to many biological processes such as cell cycle control, adaptation to stress, and cellular differentiation. Therefore, we have focused this review on the features and functions of protein kinases that distinguish trypanosomatid kinomes from other eukaryotes. We describe the latest research, highlighting similarities and differences between two groups of trypanosomatid parasites, Leishmania and African trypanosomes.

Original language	English
Pages (from-to)	950-961
Number of pages	12
Journal	Trends in parasitology
Volume	38
Issue number	11
Early online date	12 Oct 2022
DOIs	https://doi.org/10.1016/j.pt.2022.08.009
Publication status	Published - 1 Nov 2022

Bibliographical note

Keywords

cell cycle
differentiation
protein kinase

Access to Document

10.1016/j.pt.2022.08.009Licence: CC BY

Distinguishing functions of trypanosomatid protein kinases
© 2022 The Author(s).
Final published version, 1.18 MBLicence: CC BY

Cite this

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AU - Matthews, Keith R.

AU - Mottram, Jeremy C.

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