Distinguishing functions of trypanosomatid protein kinases

Research output: Contribution to journalArticlepeer-review


Trypanosomatid parasitic protozoa are divergent from opisthokont models and have evolved unique mechanisms to regulate their complex life cycles and to adapt to a range of hosts. Understanding how these organisms respond, adapt, and persist in their different hosts could reveal optimal drug-control strategies. Protein kinases are fundamental to many biological processes such as cell cycle control, adaptation to stress, and cellular differentiation. Therefore, we have focused this review on the features and functions of protein kinases that distinguish trypanosomatid kinomes from other eukaryotes. We describe the latest research, highlighting similarities and differences between two groups of trypanosomatid parasites, Leishmania and African trypanosomes.
Original languageEnglish
Pages (from-to)950-961
Number of pages12
JournalTrends in parasitology
Issue number11
Early online date12 Oct 2022
Publication statusPublished - 1 Nov 2022

Bibliographical note

© 2022 The Author(s).


  • cell cycle
  • differentiation
  • protein kinase

Cite this