The York Research Database

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

Santos, J. C., Boucher, D., Schneider, L. K., Demarco, B., Dilucca, M., Shkarina, K., Heilig, R., Chen, K. W., Lim, R. Y. H. & Broz, P., 24 Jun 2020

Article in Nature Communications

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

Heilig, R., Dilucca, M., Boucher, D., Chen, K. W., Hancz, D., Demarco, B., Shkarina, K. & Broz, P., Jun 2020

Article in Life science alliance

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

Coll, R. C., Hill, J. R., Day, C. J., Zamoshnikova, A., Boucher, D., Massey, N. L., Chitty, J. L., Fraser, J. A., Jennings, M. P., Robertson, A. A. B. & Schroder, K., Jun 2019

Article in NATURE CHEMICAL BIOLOGY

Variation in hemolysin A expression between uropathogenic Escherichia coli isolates determines NLRP3-dependent vs. -independent macrophage cell death and host colonization

Murthy, A. M. V., Sullivan, M. J., Nhu, N. T. K., Lo, A. W., Phan, M-D., Peters, K. M., Boucher, D., Schroder, K., Beatson, S. A., Ulett, G. C., Schembri, M. A. & Sweet, M. J., 14 Mar 2019

Article in The FASEB Journal

Dimerization and auto-processing induce caspase-11 protease activation within the non-canonical inflammasome

Ross, C., Chan, A. H., Von Pein, J., Boucher, D. & Schroder, K., 6 Dec 2018

Article in Life science alliance

Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection

Schaffner, A., Li, X., Gomez-Llorente, Y., Leandrou, E., Memou, A., Clemente, N., Yao, C., Afsari, F., Zhi, L., Pan, N., Morohashi, K., Hua, X., Zhou, M-M., Wang, C., Zhang, H., Chen, S. G., Elliott, C. J. H., Rideout, H., Ubarretxena-Belandia, I. & Yue, Z., Apr 2019

Article in Cell Research