Abstract
Background:
Evidence based methods for randomised controlled trial recruitment and retention are extremely valuable. Despite increased testing of these through studies within a trial, there remains limited high certainty evidence for effective strategies. In addition, there has been little consideration as to whether recruitment interventions also have an impact on participant retention.
Methods:
A systematic review was conducted. Studies were eligible if they were randomised controlled trials using a recruitment intervention and which also assessed the impact of this on retention at any timepoint. Searches were conducted through MEDLINE, EMBASE, Cochrane Library, and the Northern Ireland Hub for Trials Methodology Research SWAT Repository. Two independent reviewers screened the search results and extracted data for eligible studies using a piloted extraction form.
Results:
A total of 7815 records were identified, resulting in 10 studies being included in the review. Most studies (n=6, 60%) focused on the information given to participants (n=6, 60%), with two (20%) focussing on incentives, and two focussing on trial design and recruiter interventions. Due to intervention heterogeneity, none of the interventions could be meta-analysed. Only one study found any statistically significant effect of letters including a photograph (Odds Ratio: 5.40, 95% CI 1.12 to 26.15, p=0.04).
Conclusion:
Assessment of the impacts of recruitment strategies, evaluated in a SWAT, on retention of participants in the host trial remains limited. Assessment of the impact recruitment interventions on retention is recommended to minimise future research costs and waste.
Key Words: recruitment; retention; studies within a trial; trial methodology; systematic review
Evidence based methods for randomised controlled trial recruitment and retention are extremely valuable. Despite increased testing of these through studies within a trial, there remains limited high certainty evidence for effective strategies. In addition, there has been little consideration as to whether recruitment interventions also have an impact on participant retention.
Methods:
A systematic review was conducted. Studies were eligible if they were randomised controlled trials using a recruitment intervention and which also assessed the impact of this on retention at any timepoint. Searches were conducted through MEDLINE, EMBASE, Cochrane Library, and the Northern Ireland Hub for Trials Methodology Research SWAT Repository. Two independent reviewers screened the search results and extracted data for eligible studies using a piloted extraction form.
Results:
A total of 7815 records were identified, resulting in 10 studies being included in the review. Most studies (n=6, 60%) focused on the information given to participants (n=6, 60%), with two (20%) focussing on incentives, and two focussing on trial design and recruiter interventions. Due to intervention heterogeneity, none of the interventions could be meta-analysed. Only one study found any statistically significant effect of letters including a photograph (Odds Ratio: 5.40, 95% CI 1.12 to 26.15, p=0.04).
Conclusion:
Assessment of the impacts of recruitment strategies, evaluated in a SWAT, on retention of participants in the host trial remains limited. Assessment of the impact recruitment interventions on retention is recommended to minimise future research costs and waste.
Key Words: recruitment; retention; studies within a trial; trial methodology; systematic review
| Original language | English |
|---|---|
| Number of pages | 9 |
| Journal | Clinical trials |
| Early online date | 25 Oct 2023 |
| DOIs | |
| Publication status | E-pub ahead of print - 25 Oct 2023 |