Documenting the emergence of rheumatoid arthritis through the intersection of historical, osteological, digital and biomolecular evidence

TY - CONF

T1 - Documenting the emergence of rheumatoid arthritis through the intersection of historical, osteological, digital and biomolecular evidence

AU - Alexander, Michelle Marie

AU - Craps, Davina

AU - Schmill, Norma

AU - Holst, Malin Ragnhild

AU - Jenner, Mark

AU - Kingston, Kate

AU - Rowsell, Keri

AU - Speller, Camilla Filomena

AU - Warinner, Christina

AU - Collins, Matthew James

PY - 2015/9/19

Y1 - 2015/9/19

N2 - Rheumatoid arthritis (RA) is a much debated enigma in medical history. Some believe it is a recent disease in Europe but that it has a greater antiquity in the Americas. Others argue that the disease was present in Old World well before what is generally agreed to be the first full clinical description of the condition in the early 19thC and that the identification and thus appearance of the disease was the result of new approaches to nosology and medical theory at the time. Did it really emerge much later in Europe compared to the Americas? If so, does its late appearance give clues to its underlying cause? We are reviewing the historical and osteological evidence for the supposed ‘emergence’ of RA in Europe in the 1800s, and propose new biomolecular and digital technologies that may serve to validate ambiguous cases of RA in osteological remains, including: (i) radiography and CT to confirm diagnoses of RA; (ii) proteomics, to identify citrullinated proteins in RA skeletons; and (iii) biochemical analyses, to investigate dietary/lifestyle information (sugar consumption, tobacco use).

AB - Rheumatoid arthritis (RA) is a much debated enigma in medical history. Some believe it is a recent disease in Europe but that it has a greater antiquity in the Americas. Others argue that the disease was present in Old World well before what is generally agreed to be the first full clinical description of the condition in the early 19thC and that the identification and thus appearance of the disease was the result of new approaches to nosology and medical theory at the time. Did it really emerge much later in Europe compared to the Americas? If so, does its late appearance give clues to its underlying cause? We are reviewing the historical and osteological evidence for the supposed ‘emergence’ of RA in Europe in the 1800s, and propose new biomolecular and digital technologies that may serve to validate ambiguous cases of RA in osteological remains, including: (i) radiography and CT to confirm diagnoses of RA; (ii) proteomics, to identify citrullinated proteins in RA skeletons; and (iii) biochemical analyses, to investigate dietary/lifestyle information (sugar consumption, tobacco use).

M3 - Poster

T2 - BABAO Conference

Y2 - 18 September 2015 through 20 September 2015

ER -