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Does bleeding affect patient-reported outcome measures in patients with myelodysplasia or hematologic malignancies: a systematic review

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Does bleeding affect patient-reported outcome measures in patients with myelodysplasia or hematologic malignancies : a systematic review. / Estcourt, Lise J; Pinchon, Deborah; Symington, Emily; Kelly, Anne M; Doree, Carolyn; Brunskill, Susan; Glidewell, Liz; Stanworth, Simon J.

In: Transfusion Medicine, Vol. 54, No. 4, 04.2014, p. 1166-79.

Research output: Contribution to journalReview articlepeer-review

Harvard

Estcourt, LJ, Pinchon, D, Symington, E, Kelly, AM, Doree, C, Brunskill, S, Glidewell, L & Stanworth, SJ 2014, 'Does bleeding affect patient-reported outcome measures in patients with myelodysplasia or hematologic malignancies: a systematic review', Transfusion Medicine, vol. 54, no. 4, pp. 1166-79. https://doi.org/10.1111/trf.12441

APA

Estcourt, L. J., Pinchon, D., Symington, E., Kelly, A. M., Doree, C., Brunskill, S., Glidewell, L., & Stanworth, S. J. (2014). Does bleeding affect patient-reported outcome measures in patients with myelodysplasia or hematologic malignancies: a systematic review. Transfusion Medicine, 54(4), 1166-79. https://doi.org/10.1111/trf.12441

Vancouver

Estcourt LJ, Pinchon D, Symington E, Kelly AM, Doree C, Brunskill S et al. Does bleeding affect patient-reported outcome measures in patients with myelodysplasia or hematologic malignancies: a systematic review. Transfusion Medicine. 2014 Apr;54(4):1166-79. https://doi.org/10.1111/trf.12441

Author

Estcourt, Lise J ; Pinchon, Deborah ; Symington, Emily ; Kelly, Anne M ; Doree, Carolyn ; Brunskill, Susan ; Glidewell, Liz ; Stanworth, Simon J. / Does bleeding affect patient-reported outcome measures in patients with myelodysplasia or hematologic malignancies : a systematic review. In: Transfusion Medicine. 2014 ; Vol. 54, No. 4. pp. 1166-79.

Bibtex - Download

@article{915f16c9a85a4535a399bc54d4f04b5d,
title = "Does bleeding affect patient-reported outcome measures in patients with myelodysplasia or hematologic malignancies: a systematic review",
abstract = "BACKGROUND: Relatively minor bleeding (e.g., bruising and/or petechiae) may cause patient distress. This systematic review's objective was to assess whether bleeding affects health-related quality of life (HRQoL) or illness perceptions or representations (IPs) in patients with hematologic malignancies or myelodysplasia (MDS).STUDY DESIGN AND METHODS: We searched, in full, 12 electronic databases (including CENTRAL, MEDLINE, and EMBASE) up to January 7, 2013, for eligible randomized controlled trials (RCTs), prospective cohort studies, and cross-sectional studies.RESULTS: A total of 6247 studies were initially identified; 5945 studies were excluded on the basis of the abstract. A total of 302 full-text articles were evaluated independently by two reviewers; of these, six studies within seven citations were eligible for inclusion. Two studies are still in progress, four studies within five citations were included in this review (one RCT, one prospective observational study, one interview study, and one Web-based survey). None of the included studies were designed to assess the impact bleeding had on HRQoL or IPs. The Web-based survey and observational study used two new patient-reported outcome scales which specifically assessed patient distress or concern due to bleeding. The majority of patients within these two studies either did not experience bleeding or did not have severe thrombocytopenia.CONCLUSION: There is insufficient evidence to demonstrate whether bleeding is a significant clinical problem that affects patients' HRQoL or IPs in either patients with MDS or patients with hematologic malignancies. Rigorously designed studies to assess the scale of this problem in both of these groups of patients are required.",
keywords = "Cohort Studies, Cross-Sectional Studies, Hematologic Neoplasms, Hemorrhage, Humans, Myelodysplastic Syndromes, Prognosis, Randomized Controlled Trials as Topic, Self Concept, Self Report, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "Estcourt, {Lise J} and Deborah Pinchon and Emily Symington and Kelly, {Anne M} and Carolyn Doree and Susan Brunskill and Liz Glidewell and Stanworth, {Simon J}",
note = "{\textcopyright} 2013 American Association of Blood Banks.",
year = "2014",
month = apr,
doi = "10.1111/trf.12441",
language = "English",
volume = "54",
pages = "1166--79",
journal = "Transfusion Medicine",
issn = "0958-7578",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Does bleeding affect patient-reported outcome measures in patients with myelodysplasia or hematologic malignancies

T2 - a systematic review

AU - Estcourt, Lise J

AU - Pinchon, Deborah

AU - Symington, Emily

AU - Kelly, Anne M

AU - Doree, Carolyn

AU - Brunskill, Susan

AU - Glidewell, Liz

AU - Stanworth, Simon J

N1 - © 2013 American Association of Blood Banks.

PY - 2014/4

Y1 - 2014/4

N2 - BACKGROUND: Relatively minor bleeding (e.g., bruising and/or petechiae) may cause patient distress. This systematic review's objective was to assess whether bleeding affects health-related quality of life (HRQoL) or illness perceptions or representations (IPs) in patients with hematologic malignancies or myelodysplasia (MDS).STUDY DESIGN AND METHODS: We searched, in full, 12 electronic databases (including CENTRAL, MEDLINE, and EMBASE) up to January 7, 2013, for eligible randomized controlled trials (RCTs), prospective cohort studies, and cross-sectional studies.RESULTS: A total of 6247 studies were initially identified; 5945 studies were excluded on the basis of the abstract. A total of 302 full-text articles were evaluated independently by two reviewers; of these, six studies within seven citations were eligible for inclusion. Two studies are still in progress, four studies within five citations were included in this review (one RCT, one prospective observational study, one interview study, and one Web-based survey). None of the included studies were designed to assess the impact bleeding had on HRQoL or IPs. The Web-based survey and observational study used two new patient-reported outcome scales which specifically assessed patient distress or concern due to bleeding. The majority of patients within these two studies either did not experience bleeding or did not have severe thrombocytopenia.CONCLUSION: There is insufficient evidence to demonstrate whether bleeding is a significant clinical problem that affects patients' HRQoL or IPs in either patients with MDS or patients with hematologic malignancies. Rigorously designed studies to assess the scale of this problem in both of these groups of patients are required.

AB - BACKGROUND: Relatively minor bleeding (e.g., bruising and/or petechiae) may cause patient distress. This systematic review's objective was to assess whether bleeding affects health-related quality of life (HRQoL) or illness perceptions or representations (IPs) in patients with hematologic malignancies or myelodysplasia (MDS).STUDY DESIGN AND METHODS: We searched, in full, 12 electronic databases (including CENTRAL, MEDLINE, and EMBASE) up to January 7, 2013, for eligible randomized controlled trials (RCTs), prospective cohort studies, and cross-sectional studies.RESULTS: A total of 6247 studies were initially identified; 5945 studies were excluded on the basis of the abstract. A total of 302 full-text articles were evaluated independently by two reviewers; of these, six studies within seven citations were eligible for inclusion. Two studies are still in progress, four studies within five citations were included in this review (one RCT, one prospective observational study, one interview study, and one Web-based survey). None of the included studies were designed to assess the impact bleeding had on HRQoL or IPs. The Web-based survey and observational study used two new patient-reported outcome scales which specifically assessed patient distress or concern due to bleeding. The majority of patients within these two studies either did not experience bleeding or did not have severe thrombocytopenia.CONCLUSION: There is insufficient evidence to demonstrate whether bleeding is a significant clinical problem that affects patients' HRQoL or IPs in either patients with MDS or patients with hematologic malignancies. Rigorously designed studies to assess the scale of this problem in both of these groups of patients are required.

KW - Cohort Studies

KW - Cross-Sectional Studies

KW - Hematologic Neoplasms

KW - Hemorrhage

KW - Humans

KW - Myelodysplastic Syndromes

KW - Prognosis

KW - Randomized Controlled Trials as Topic

KW - Self Concept

KW - Self Report

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1111/trf.12441

DO - 10.1111/trf.12441

M3 - Review article

C2 - 24117481

VL - 54

SP - 1166

EP - 1179

JO - Transfusion Medicine

JF - Transfusion Medicine

SN - 0958-7578

IS - 4

ER -