TY - JOUR
T1 - Double-aberration corrected TEM/STEM of solid acid nanocatalysts in the development of pharmaceutical NSAIDS
AU - Yoshida, K.
AU - Gai, P.L.
AU - Wright, I.
AU - Boyes, E.D.
AU - Shiju, N.
AU - Brown, R.
PY - 2012/1/1
Y1 - 2012/1/1
N2 - We report nanostructural and physico-chemical studies in the development of an efficient low temperature heterogeneous catalytic process for nonsteroidal anti-inflammatory drugs (NSAIDS) such as N-acetyl-p-aminophenol (paracetamol or acetaminophen) on tungstated zirconia nanocatalysts. Using a double-aberration corrected TEM/STEM, modified in-house for in-situ studies at the sub-Angstrom level, we directly observed in real-time, the dynamic precursor transformation to the active catalyst. We quantified the observations with catalytic activity studies for the NSAIDS. The studies have provided the direct evidence for single tungsten promoter atoms and surface WO species of ≤ 0.35 nm, with nanoclusters of WO (0.6 to 1nm), located at grain boundaries on the surface of the zirconia nanoparticles. The correlation between the nanostructure and catalytic activity indicates that the species create Brønsted acid sites highly active for the low temperature process. The results open up opportunities for developing green heterogeneous methods for pharmaceuticals.
AB - We report nanostructural and physico-chemical studies in the development of an efficient low temperature heterogeneous catalytic process for nonsteroidal anti-inflammatory drugs (NSAIDS) such as N-acetyl-p-aminophenol (paracetamol or acetaminophen) on tungstated zirconia nanocatalysts. Using a double-aberration corrected TEM/STEM, modified in-house for in-situ studies at the sub-Angstrom level, we directly observed in real-time, the dynamic precursor transformation to the active catalyst. We quantified the observations with catalytic activity studies for the NSAIDS. The studies have provided the direct evidence for single tungsten promoter atoms and surface WO species of ≤ 0.35 nm, with nanoclusters of WO (0.6 to 1nm), located at grain boundaries on the surface of the zirconia nanoparticles. The correlation between the nanostructure and catalytic activity indicates that the species create Brønsted acid sites highly active for the low temperature process. The results open up opportunities for developing green heterogeneous methods for pharmaceuticals.
UR - http://www.scopus.com/inward/record.url?scp=84865421873&partnerID=8YFLogxK
U2 - 10.1088/1742-6596/371/1/012026
DO - 10.1088/1742-6596/371/1/012026
M3 - Article
AN - SCOPUS:84865421873
SN - 1742-6588
VL - 371
JO - Journal of Physics: Conference Series
JF - Journal of Physics: Conference Series
M1 - 012026
ER -