Early transcriptionaltargetsofMyoDlinkmyogenesisandsomitogenesis

Richard Maguire; Harry Victor Isaacs

Early transcriptionaltargetsofMyoDlinkmyogenesisandsomitogenesis

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

In ordertoidentifyearlytranscriptionaltargetsofMyoDpriortoskeletalmuscledifferentiation,we
have undertakenatranscriptomicanalysisongastrulastage Xenopus embryosinwhichMyoDhasbeen
knocked-down.OurvalidatedlistofgenestranscriptionallyregulatedbyMyoDincludes Esr1 and Esr2,
which areknowntargetsofNotch signalling, and Tbx6, mesogenin, and FoxC1; thesegenesareallare
known tobeessentialfornormalsomitogenesisbutareexpressedsurprisinglyearlyinthemesoderm.
In additionwefoundthatMyoDisrequiredfortheexpressionof myf5 in theearlymesoderm,in
contrasttothereverserelationshipofthesetworegulatorsinamniotesomites.Thesedatahighlighta
role forMyoDintheearlymesoderminregulatingasetofgenesthatareessentialforbothmyogenesis
and somitogenesis.

Original language	English
Journal	Developmental Biology
Publication status	Accepted/In press - 2012

Transcriptional responses to FGF signalling...
Isaacs, H. V. (Principal investigator)
BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL)
1/03/06 → 31/05/09
Project: Research project (funded) › Research

Cite this

@article{9a39b9f1a91040328ed8dc55d48d0f55,

title = "Early transcriptionaltargetsofMyoDlinkmyogenesisandsomitogenesis",

abstract = "In ordertoidentifyearlytranscriptionaltargetsofMyoDpriortoskeletalmuscledifferentiation,wehave undertakenatranscriptomicanalysisongastrulastage Xenopus embryosinwhichMyoDhasbeenknocked-down.OurvalidatedlistofgenestranscriptionallyregulatedbyMyoDincludes Esr1 and Esr2,which areknowntargetsofNotch signalling, and Tbx6, mesogenin, and FoxC1; thesegenesareallareknown tobeessentialfornormalsomitogenesisbutareexpressedsurprisinglyearlyinthemesoderm.In additionwefoundthatMyoDisrequiredfortheexpressionof myf5 in theearlymesoderm,incontrasttothereverserelationshipofthesetworegulatorsinamniotesomites.Thesedatahighlightarole forMyoDintheearlymesoderminregulatingasetofgenesthatareessentialforbothmyogenesisand somitogenesis.",

author = "Richard Maguire and Isaacs, {Harry Victor}",

year = "2012",

language = "English",

journal = "Developmental Biology",

issn = "0012-1606",

publisher = "Academic Press",

}

TY - JOUR

T1 - Early transcriptionaltargetsofMyoDlinkmyogenesisandsomitogenesis

AU - Maguire, Richard

AU - Isaacs, Harry Victor

PY - 2012

Y1 - 2012

N2 - In ordertoidentifyearlytranscriptionaltargetsofMyoDpriortoskeletalmuscledifferentiation,wehave undertakenatranscriptomicanalysisongastrulastage Xenopus embryosinwhichMyoDhasbeenknocked-down.OurvalidatedlistofgenestranscriptionallyregulatedbyMyoDincludes Esr1 and Esr2,which areknowntargetsofNotch signalling, and Tbx6, mesogenin, and FoxC1; thesegenesareallareknown tobeessentialfornormalsomitogenesisbutareexpressedsurprisinglyearlyinthemesoderm.In additionwefoundthatMyoDisrequiredfortheexpressionof myf5 in theearlymesoderm,incontrasttothereverserelationshipofthesetworegulatorsinamniotesomites.Thesedatahighlightarole forMyoDintheearlymesoderminregulatingasetofgenesthatareessentialforbothmyogenesisand somitogenesis.

AB - In ordertoidentifyearlytranscriptionaltargetsofMyoDpriortoskeletalmuscledifferentiation,wehave undertakenatranscriptomicanalysisongastrulastage Xenopus embryosinwhichMyoDhasbeenknocked-down.OurvalidatedlistofgenestranscriptionallyregulatedbyMyoDincludes Esr1 and Esr2,which areknowntargetsofNotch signalling, and Tbx6, mesogenin, and FoxC1; thesegenesareallareknown tobeessentialfornormalsomitogenesisbutareexpressedsurprisinglyearlyinthemesoderm.In additionwefoundthatMyoDisrequiredfortheexpressionof myf5 in theearlymesoderm,incontrasttothereverserelationshipofthesetworegulatorsinamniotesomites.Thesedatahighlightarole forMyoDintheearlymesoderminregulatingasetofgenesthatareessentialforbothmyogenesisand somitogenesis.

M3 - Article

SN - 0012-1606

JO - Developmental Biology

JF - Developmental Biology

ER -

Early transcriptionaltargetsofMyoDlinkmyogenesisandsomitogenesis

Abstract

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Transcriptional responses to FGF signalling...

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