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Early transcriptionaltargetsofMyoDlinkmyogenesisandsomitogenesis
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Publication details
| Journal | Developmental Biology |
|---|---|
| Date | Accepted/In press - 2012 |
| Original language | English |
Abstract
In ordertoidentifyearlytranscriptionaltargetsofMyoDpriortoskeletalmuscledifferentiation,we
have undertakenatranscriptomicanalysisongastrulastage Xenopus embryosinwhichMyoDhasbeen
knocked-down.OurvalidatedlistofgenestranscriptionallyregulatedbyMyoDincludes Esr1 and Esr2,
which areknowntargetsofNotch signalling, and Tbx6, mesogenin, and FoxC1; thesegenesareallare
known tobeessentialfornormalsomitogenesisbutareexpressedsurprisinglyearlyinthemesoderm.
In additionwefoundthatMyoDisrequiredfortheexpressionof myf5 in theearlymesoderm,in
contrasttothereverserelationshipofthesetworegulatorsinamniotesomites.Thesedatahighlighta
role forMyoDintheearlymesoderminregulatingasetofgenesthatareessentialforbothmyogenesis
and somitogenesis.
have undertakenatranscriptomicanalysisongastrulastage Xenopus embryosinwhichMyoDhasbeen
knocked-down.OurvalidatedlistofgenestranscriptionallyregulatedbyMyoDincludes Esr1 and Esr2,
which areknowntargetsofNotch signalling, and Tbx6, mesogenin, and FoxC1; thesegenesareallare
known tobeessentialfornormalsomitogenesisbutareexpressedsurprisinglyearlyinthemesoderm.
In additionwefoundthatMyoDisrequiredfortheexpressionof myf5 in theearlymesoderm,in
contrasttothereverserelationshipofthesetworegulatorsinamniotesomites.Thesedatahighlighta
role forMyoDintheearlymesoderminregulatingasetofgenesthatareessentialforbothmyogenesis
and somitogenesis.
Projects
Transcriptional responses to FGF signalling...
Project: Research project (funded) › Research
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