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Early transcriptionaltargetsofMyoDlinkmyogenesisandsomitogenesis

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JournalDevelopmental Biology
DateAccepted/In press - 2012
Original languageEnglish

Abstract

In ordertoidentifyearlytranscriptionaltargetsofMyoDpriortoskeletalmuscledifferentiation,we
have undertakenatranscriptomicanalysisongastrulastage Xenopus embryosinwhichMyoDhasbeen
knocked-down.OurvalidatedlistofgenestranscriptionallyregulatedbyMyoDincludes Esr1 and Esr2,
which areknowntargetsofNotch signalling, and Tbx6, mesogenin, and FoxC1; thesegenesareallare
known tobeessentialfornormalsomitogenesisbutareexpressedsurprisinglyearlyinthemesoderm.
In additionwefoundthatMyoDisrequiredfortheexpressionof myf5 in theearlymesoderm,in
contrasttothereverserelationshipofthesetworegulatorsinamniotesomites.Thesedatahighlighta
role forMyoDintheearlymesoderminregulatingasetofgenesthatareessentialforbothmyogenesis
and somitogenesis.

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