Economic analysis of vaccination programs

Josephine Mauskopf*, Baudouin Standaert, Mark P. Connolly, Anthony J. Culyer, Louis P. Garrison, Raymond Hutubessy, Mark Jit, Richard Pitman, Paul Revill, Johan L. Severens

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


This report provides recommendations for budget holders and decision makers in high-, middle, and low-income countries requiring economic analyses of new vaccination programs to allocate scarce resources given budget constraints. ISPOR's Economic Evaluation of Vaccines Designed to Prevent Infectious Disease: Good Practices Task Force wrote guidelines for three analytic methods and solicited comments on them from external reviewers. Cost-effectiveness analyses use decision-analytic models to estimate cumulative changes in resource use, costs, and changes in quality- or disability-adjusted life-years attributable to changes in disease outcomes. Constrained optimization modeling uses a mathematical objective function to be optimized (e.g. disease cases avoided) for a target population for a set of interventions including vaccination programs within established constraints. Fiscal health modeling estimates changes in net present value of government revenues and expenditures attributable to changes in disease outcomes. The task force recommends that those designing economic analyses for new vaccination programs take into account the decision maker's policy objectives and country-specific decision context when estimating: uptake rate in the target population; vaccination program's impact on disease cases in the population over time using a dynamic transmission epidemiologic model; vaccination program implementation and operating costs; and the changes in costs and health outcomes of the target disease(s). The three approaches to economic analysis are complementary and can be used alone or together to estimate a vaccination program's economic value for national, regional, or subregional decision makers in high-, middle-, and low-income countries.

Original languageEnglish
Pages (from-to)1133-1149
Number of pages17
JournalValue in Health
Issue number10
Publication statusPublished - 1 Oct 2018

Bibliographical note

& 2018, ISPOR–The Professional Society for Health Economics and Outcomes Research. Published by Elsevier IncThis is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy


  • constrained optimization modeling
  • cost-effectiveness analysis
  • fiscal health modeling
  • vaccination program

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