Abstract
Objectives: Tegaserod is effective, safe, and well-tolerated in the treatment of patients with irritable bowel syndrome (IBS) with constipation. The aim of this study was to assess, from a payer perspective, the cost-effectiveness of tegaserod in the treatment of IBS patients, based on the TEgaserod in NORdic region (TENOR) trial data.
Methods: Female and male patients (Rome 11 criteria) were randomized to receive tegaserod 6 mg b.i.d. or placebo for 12 weeks. Patients (247 tegaserod; 238 placebo) completed the EuroQol EQ-5D questionnaire at baseline, Week 4, and Week 12. A 12-week economic study was undertaken to assess the incremental cost-effectiveness ratio (ICER) of tegaserod in terms of cost per quality-adjusted life-year (QALY) gained. Cost-effectiveness acceptability curves were calculated toestimate the probability of tegaserod being cost-effective at different benchmark values of cost per QALY gained.
Results: By assuming a daily drug cost to payers of 2euro, 3euro, and 4euro, the ICER of tegascrod ranges between 19,000euro and 38,000euro per QALY gained, with the percentage of the bootstrap estimates below the willingness to pay level of 50,000 per QALY gained ranging between 90% and 69%.
Conclusions: This study established directly from a randomized controlled clinical trial that tegaserod is cost-effective in the treatment of non-D-IBS patients.
| Original language | English |
|---|---|
| Pages (from-to) | 238-246 |
| Number of pages | 9 |
| Journal | Value in Health |
| Volume | 10 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2007 |
Keywords
- clinical trial
- constipation
- irritable bowel syndrome
- Nordic
- quality of life
- quality-adjusted life-years
- tegaserod
- therapeutic
- QUALITY-OF-LIFE
- FUNCTIONAL GASTROINTESTINAL DISORDERS
- COST-EFFECTIVENESS ANALYSIS
- UNITED-STATES
- DOUBLE-BLIND
- BASE-LINE
- CONTROLLED-TRIALS
- CLINICAL-TRIAL
- CONSTIPATION
- IMPACT