Ecotoxicity of transformation products

Research output: Chapter in Book/Report/Conference proceedingChapter

Standard

Ecotoxicity of transformation products. / Sinclair, Chris J.; Boxall, Alistair B A.

Handbook of Environmental Chemistry, Volume 2: Reactions and Processes. Vol. 2 P 2009. p. 177-204 (Handbook of Environmental Chemistry, Volume 2: Reactions and Processes; Vol. 2 P).

Research output: Chapter in Book/Report/Conference proceedingChapter

Harvard

Sinclair, CJ & Boxall, ABA 2009, Ecotoxicity of transformation products. in Handbook of Environmental Chemistry, Volume 2: Reactions and Processes. vol. 2 P, Handbook of Environmental Chemistry, Volume 2: Reactions and Processes, vol. 2 P, pp. 177-204. https://doi.org/10.1007/698_2_019

APA

Sinclair, C. J., & Boxall, A. B. A. (2009). Ecotoxicity of transformation products. In Handbook of Environmental Chemistry, Volume 2: Reactions and Processes (Vol. 2 P, pp. 177-204). (Handbook of Environmental Chemistry, Volume 2: Reactions and Processes; Vol. 2 P). https://doi.org/10.1007/698_2_019

Vancouver

Sinclair CJ, Boxall ABA. Ecotoxicity of transformation products. In Handbook of Environmental Chemistry, Volume 2: Reactions and Processes. Vol. 2 P. 2009. p. 177-204. (Handbook of Environmental Chemistry, Volume 2: Reactions and Processes). https://doi.org/10.1007/698_2_019

Author

Sinclair, Chris J. ; Boxall, Alistair B A. / Ecotoxicity of transformation products. Handbook of Environmental Chemistry, Volume 2: Reactions and Processes. Vol. 2 P 2009. pp. 177-204 (Handbook of Environmental Chemistry, Volume 2: Reactions and Processes).

Bibtex - Download

@inbook{b0ccfc63caea4e9eb6dbdb9b745af4a4,
title = "Ecotoxicity of transformation products",
abstract = "While a large body of information is available on the environmental effects of parent chemicals, we know much less about the effects of transformation products. However, transformation products may be more toxic, more persistent and more mobile than their parent compound. An understanding of the ecotoxicity of transformation products is therefore essential if we are to accurately assess the environmental risks of synthetic chemicals. This chapter therefore uses data on pesticides and their transformation products to explore the relationships between parent and transformation product ecotoxicity to aquatic and terrestrial organisms and describes the potential reasons why a transformation product may be more toxic than its parent compound. As it is not feasible to experimentally assess the ecotoxicity of each and every transformation product, this chapter also describes and evaluates the use of expert systems, read-across methods and quantitative structure activity relationships for estimating transformation product ecotoxicity based on chemical structure. Finally, experimental and predicted ecotoxicity data are used alongside monitoring data for parent pesticides and their transformation products to illustrate how the risks of parent and transformation product mixtures can be assessed.",
keywords = "Ecotoxicity, Expert systems, Mixture, Mode of action, QSAR, Read-across, Toxicity",
author = "Sinclair, {Chris J.} and Boxall, {Alistair B A}",
year = "2009",
doi = "10.1007/698_2_019",
language = "English",
isbn = "9783540882725",
volume = "2 P",
series = "Handbook of Environmental Chemistry, Volume 2: Reactions and Processes",
pages = "177--204",
booktitle = "Handbook of Environmental Chemistry, Volume 2: Reactions and Processes",

}

RIS (suitable for import to EndNote) - Download

TY - CHAP

T1 - Ecotoxicity of transformation products

AU - Sinclair, Chris J.

AU - Boxall, Alistair B A

PY - 2009

Y1 - 2009

N2 - While a large body of information is available on the environmental effects of parent chemicals, we know much less about the effects of transformation products. However, transformation products may be more toxic, more persistent and more mobile than their parent compound. An understanding of the ecotoxicity of transformation products is therefore essential if we are to accurately assess the environmental risks of synthetic chemicals. This chapter therefore uses data on pesticides and their transformation products to explore the relationships between parent and transformation product ecotoxicity to aquatic and terrestrial organisms and describes the potential reasons why a transformation product may be more toxic than its parent compound. As it is not feasible to experimentally assess the ecotoxicity of each and every transformation product, this chapter also describes and evaluates the use of expert systems, read-across methods and quantitative structure activity relationships for estimating transformation product ecotoxicity based on chemical structure. Finally, experimental and predicted ecotoxicity data are used alongside monitoring data for parent pesticides and their transformation products to illustrate how the risks of parent and transformation product mixtures can be assessed.

AB - While a large body of information is available on the environmental effects of parent chemicals, we know much less about the effects of transformation products. However, transformation products may be more toxic, more persistent and more mobile than their parent compound. An understanding of the ecotoxicity of transformation products is therefore essential if we are to accurately assess the environmental risks of synthetic chemicals. This chapter therefore uses data on pesticides and their transformation products to explore the relationships between parent and transformation product ecotoxicity to aquatic and terrestrial organisms and describes the potential reasons why a transformation product may be more toxic than its parent compound. As it is not feasible to experimentally assess the ecotoxicity of each and every transformation product, this chapter also describes and evaluates the use of expert systems, read-across methods and quantitative structure activity relationships for estimating transformation product ecotoxicity based on chemical structure. Finally, experimental and predicted ecotoxicity data are used alongside monitoring data for parent pesticides and their transformation products to illustrate how the risks of parent and transformation product mixtures can be assessed.

KW - Ecotoxicity

KW - Expert systems

KW - Mixture

KW - Mode of action

KW - QSAR

KW - Read-across

KW - Toxicity

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U2 - 10.1007/698_2_019

DO - 10.1007/698_2_019

M3 - Chapter

AN - SCOPUS:70249130148

SN - 9783540882725

VL - 2 P

T3 - Handbook of Environmental Chemistry, Volume 2: Reactions and Processes

SP - 177

EP - 204

BT - Handbook of Environmental Chemistry, Volume 2: Reactions and Processes

ER -