Effect modification and non-collapsibility together may lead to conflicting treatment decisions: a review of marginal and conditional estimands and recommendations for decision-making

David M. Phillippo; Antonio Remiro-Azócar; Anna Heath; Gianluca Baio; Sofia Dias; A.E. Ades; Nicky J Welton

doi:10.1017/rsm.2025.2

Effect modification and non-collapsibility together may lead to conflicting treatment decisions: a review of marginal and conditional estimands and recommendations for decision-making

David M. Phillippo^*, Antonio Remiro-Azócar, Anna Heath, Gianluca Baio, Sofia Dias, A.E. Ades, Nicky J Welton

^*Corresponding author for this work

Centre for Reviews and Dissemination

Research output: Contribution to journal › Article › peer-review

Original language	English
Number of pages	27
Journal	Research Synthesis Methods
Early online date	10 Mar 2025
DOIs	https://doi.org/10.1017/rsm.2025.2
Publication status	E-pub ahead of print - 10 Mar 2025

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10.1017/rsm.2025.2Licence: CC BY

Effect modification and non-collapsibility together may lead to conflicting treatment decisions: A review of marginal and conditional estimands and recommendations for decision-making
© The Author(s), 2025
Final published version, 2.96 MBLicence: CC BY

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Phillippo, D. M., Remiro-Azócar, A., Heath, A., Baio, G., Dias, S., Ades, A. E., & Welton, N. J. (2025). Effect modification and non-collapsibility together may lead to conflicting treatment decisions: a review of marginal and conditional estimands and recommendations for decision-making. Research Synthesis Methods. Advance online publication. https://doi.org/10.1017/rsm.2025.2

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