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Effect of buffer at nanoscale molecular recognition interfaces - electrostatic binding of biological polyanions

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JournalChemical communications
DateAccepted/In press - 5 Oct 2017
DatePublished (current) - 9 Oct 2017
Volume53
Pages (from-to)11580-11583
Original languageEnglish

Abstract

We investigate the impact of an over-looked component on molecular recognition in water–buffer. The binding of a cationic dye to biological polyanion heparin is shown by isothermal calorimetry to depend on buffer (Tris–HCl > HEPES > PBS). The heparin binding of self-assembled multivalent (SAMul) cationic micelles is even more buffer dependent. Multivalent electrostatic molecular recognition is buffer dependent as a result of competitive interactions between the cationic binding interface and anions present in the buffer.

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