By the same authors

From the same journal

From the same journal

Effect of buffer at nanoscale molecular recognition interfaces - electrostatic binding of biological polyanions

Research output: Contribution to journalArticlepeer-review

Full text download(s)



Publication details

JournalChemical communications
DateAccepted/In press - 5 Oct 2017
DatePublished (current) - 9 Oct 2017
Pages (from-to)11580-11583
Original languageEnglish


We investigate the impact of an over-looked component on molecular recognition in water–buffer. The binding of a cationic dye to biological polyanion heparin is shown by isothermal calorimetry to depend on buffer (Tris–HCl > HEPES > PBS). The heparin binding of self-assembled multivalent (SAMul) cationic micelles is even more buffer dependent. Multivalent electrostatic molecular recognition is buffer dependent as a result of competitive interactions between the cationic binding interface and anions present in the buffer.

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations