Effect of combined oxidative and nitrosative stress on Neisseria meningitidis

K Dyet; J Moir

Effect of combined oxidative and nitrosative stress on Neisseria meningitidis

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Reactive oxygen and nitrogen species are produced by the human immune system in response to infection. Methods to detoxify these reactive species are vital to the survival of human pathogens, such as Neisseria meningitidis, which is the major aetiological agent of bacterial meningitis. Following activation, macrophages produce superoxide (O-2(-)), hydrogen peroxide (H2O2) and nitric oxide (NO). The toxicity Of O-2(-), generated using X/Xo (xanthine/xanthine oxidase), and H2O2 was investigated in the presence and absence of the NO donor DEA-NONOate [2-(N,N-diethylamino)-diazenolate-2-oxide diethylammonium salt]. Most of the toxicity from X/Xo was due to H2O2. In N. meningitidis, NO decreased the toxicity of the H2O2. in contrast, in the enteric bacterium Escherichia coli, No increased the toxicity of the H2O2.

Original language	English
Pages (from-to)	197-199
Number of pages	3
Journal	Biochemical Society transactions
Volume	34
Publication status	Published - Feb 2006

Keywords

hydrogen peroxide
Neisseria meningitidis
nitric oxide
nitrosative stress
oxidative stress
superoxide
ESCHERICHIA-COLI
GONORRHOEAE
SURVIVAL
DEFENSES
SYSTEMS

Nitric oxide reactive oxygen species their interplay and detoxification in Neisseria meningitidis
Moir, J.
BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL)
19/07/04 → 18/01/08
Project: Research project (funded) › Research

Cite this

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title = "Effect of combined oxidative and nitrosative stress on Neisseria meningitidis",

abstract = "Reactive oxygen and nitrogen species are produced by the human immune system in response to infection. Methods to detoxify these reactive species are vital to the survival of human pathogens, such as Neisseria meningitidis, which is the major aetiological agent of bacterial meningitis. Following activation, macrophages produce superoxide (O-2(-)), hydrogen peroxide (H2O2) and nitric oxide (NO). The toxicity Of O-2(-), generated using X/Xo (xanthine/xanthine oxidase), and H2O2 was investigated in the presence and absence of the NO donor DEA-NONOate [2-(N,N-diethylamino)-diazenolate-2-oxide diethylammonium salt]. Most of the toxicity from X/Xo was due to H2O2. In N. meningitidis, NO decreased the toxicity of the H2O2. in contrast, in the enteric bacterium Escherichia coli, No increased the toxicity of the H2O2.",

keywords = "hydrogen peroxide, Neisseria meningitidis, nitric oxide, nitrosative stress, oxidative stress, superoxide, ESCHERICHIA-COLI, GONORRHOEAE, SURVIVAL, DEFENSES, SYSTEMS",

author = "K Dyet and J Moir",

year = "2006",

month = feb,

language = "English",

volume = "34",

pages = "197--199",

journal = "Biochemical Society transactions",

issn = "1470-8752",

publisher = "Portland Press Ltd.",

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TY - JOUR

T1 - Effect of combined oxidative and nitrosative stress on Neisseria meningitidis

AU - Dyet, K

AU - Moir, J

PY - 2006/2

Y1 - 2006/2

N2 - Reactive oxygen and nitrogen species are produced by the human immune system in response to infection. Methods to detoxify these reactive species are vital to the survival of human pathogens, such as Neisseria meningitidis, which is the major aetiological agent of bacterial meningitis. Following activation, macrophages produce superoxide (O-2(-)), hydrogen peroxide (H2O2) and nitric oxide (NO). The toxicity Of O-2(-), generated using X/Xo (xanthine/xanthine oxidase), and H2O2 was investigated in the presence and absence of the NO donor DEA-NONOate [2-(N,N-diethylamino)-diazenolate-2-oxide diethylammonium salt]. Most of the toxicity from X/Xo was due to H2O2. In N. meningitidis, NO decreased the toxicity of the H2O2. in contrast, in the enteric bacterium Escherichia coli, No increased the toxicity of the H2O2.

AB - Reactive oxygen and nitrogen species are produced by the human immune system in response to infection. Methods to detoxify these reactive species are vital to the survival of human pathogens, such as Neisseria meningitidis, which is the major aetiological agent of bacterial meningitis. Following activation, macrophages produce superoxide (O-2(-)), hydrogen peroxide (H2O2) and nitric oxide (NO). The toxicity Of O-2(-), generated using X/Xo (xanthine/xanthine oxidase), and H2O2 was investigated in the presence and absence of the NO donor DEA-NONOate [2-(N,N-diethylamino)-diazenolate-2-oxide diethylammonium salt]. Most of the toxicity from X/Xo was due to H2O2. In N. meningitidis, NO decreased the toxicity of the H2O2. in contrast, in the enteric bacterium Escherichia coli, No increased the toxicity of the H2O2.

KW - hydrogen peroxide

KW - Neisseria meningitidis

KW - nitric oxide

KW - nitrosative stress

KW - oxidative stress

KW - superoxide

KW - ESCHERICHIA-COLI

KW - GONORRHOEAE

KW - SURVIVAL

KW - DEFENSES

KW - SYSTEMS

M3 - Article

SN - 1470-8752

VL - 34

SP - 197

EP - 199

JO - Biochemical Society transactions

JF - Biochemical Society transactions

ER -

Effect of combined oxidative and nitrosative stress on Neisseria meningitidis

Abstract

Keywords

Projects

Nitric oxide reactive oxygen species their interplay and detoxification in Neisseria meningitidis

Cite this