Effect of oligomer length on vibrational coupling and energy relaxation in double-stranded DNA

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Effect of oligomer length on vibrational coupling and energy relaxation in double-stranded DNA. / Hithell, Gordon; Donaldson, Paul M.; Greetham, Gregory M.; Towrie, Michael; Parker, Anthony W.; Burley, Glenn A.; Hunt, Neil T.

In: Chemical Physics, Vol. 512, 17.08.2018, p. 154-164.

Research output: Contribution to journalArticle

Harvard

Hithell, G, Donaldson, PM, Greetham, GM, Towrie, M, Parker, AW, Burley, GA & Hunt, NT 2018, 'Effect of oligomer length on vibrational coupling and energy relaxation in double-stranded DNA', Chemical Physics, vol. 512, pp. 154-164. https://doi.org/10.1016/j.chemphys.2017.12.010

APA

Hithell, G., Donaldson, P. M., Greetham, G. M., Towrie, M., Parker, A. W., Burley, G. A., & Hunt, N. T. (2018). Effect of oligomer length on vibrational coupling and energy relaxation in double-stranded DNA. Chemical Physics, 512, 154-164. https://doi.org/10.1016/j.chemphys.2017.12.010

Vancouver

Hithell G, Donaldson PM, Greetham GM, Towrie M, Parker AW, Burley GA et al. Effect of oligomer length on vibrational coupling and energy relaxation in double-stranded DNA. Chemical Physics. 2018 Aug 17;512:154-164. https://doi.org/10.1016/j.chemphys.2017.12.010

Author

Hithell, Gordon ; Donaldson, Paul M. ; Greetham, Gregory M. ; Towrie, Michael ; Parker, Anthony W. ; Burley, Glenn A. ; Hunt, Neil T. / Effect of oligomer length on vibrational coupling and energy relaxation in double-stranded DNA. In: Chemical Physics. 2018 ; Vol. 512. pp. 154-164.

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@article{c978948aff81426f8c008c077244106d,
title = "Effect of oligomer length on vibrational coupling and energy relaxation in double-stranded DNA",
abstract = "The effect of oligomer length on the vibrational mode coupling and energy relaxation mechanisms of AT-rich DNA oligomers in double- and single-stranded conformations has been investigated using two-dimensional infrared spectroscopy. Vibrational coupling of modes of the DNA bases to the symmetric stretching vibration of the backbone phosphate group was observed for oligomers long enough to form duplex-DNA structures. The coupling was lost upon melting of the duplex. No significant effect of oligomer length or DNA secondary structure was found on either the timescale for vibrational relaxation of the base modes or the mechanism, which was consistent with a cascade process from base modes to intermediate modes, some of which are located on the deoxyribose group, and subsequently to the phosphate backbone. The study shows that vibrational coupling between base and backbone requires formation of the double-helix structure while vibrational energy management is an inherent property of the nucleotide.",
keywords = "DNA, Infrared, Ultrafast spectroscopy, Vibrational coupling, Vibrational relaxation",
author = "Gordon Hithell and Donaldson, {Paul M.} and Greetham, {Gregory M.} and Michael Towrie and Parker, {Anthony W.} and Burley, {Glenn A.} and Hunt, {Neil T.}",
year = "2018",
month = "8",
day = "17",
doi = "10.1016/j.chemphys.2017.12.010",
language = "English",
volume = "512",
pages = "154--164",
journal = "Chemical Physics",
issn = "0301-0104",
publisher = "Elsevier",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Effect of oligomer length on vibrational coupling and energy relaxation in double-stranded DNA

AU - Hithell, Gordon

AU - Donaldson, Paul M.

AU - Greetham, Gregory M.

AU - Towrie, Michael

AU - Parker, Anthony W.

AU - Burley, Glenn A.

AU - Hunt, Neil T.

PY - 2018/8/17

Y1 - 2018/8/17

N2 - The effect of oligomer length on the vibrational mode coupling and energy relaxation mechanisms of AT-rich DNA oligomers in double- and single-stranded conformations has been investigated using two-dimensional infrared spectroscopy. Vibrational coupling of modes of the DNA bases to the symmetric stretching vibration of the backbone phosphate group was observed for oligomers long enough to form duplex-DNA structures. The coupling was lost upon melting of the duplex. No significant effect of oligomer length or DNA secondary structure was found on either the timescale for vibrational relaxation of the base modes or the mechanism, which was consistent with a cascade process from base modes to intermediate modes, some of which are located on the deoxyribose group, and subsequently to the phosphate backbone. The study shows that vibrational coupling between base and backbone requires formation of the double-helix structure while vibrational energy management is an inherent property of the nucleotide.

AB - The effect of oligomer length on the vibrational mode coupling and energy relaxation mechanisms of AT-rich DNA oligomers in double- and single-stranded conformations has been investigated using two-dimensional infrared spectroscopy. Vibrational coupling of modes of the DNA bases to the symmetric stretching vibration of the backbone phosphate group was observed for oligomers long enough to form duplex-DNA structures. The coupling was lost upon melting of the duplex. No significant effect of oligomer length or DNA secondary structure was found on either the timescale for vibrational relaxation of the base modes or the mechanism, which was consistent with a cascade process from base modes to intermediate modes, some of which are located on the deoxyribose group, and subsequently to the phosphate backbone. The study shows that vibrational coupling between base and backbone requires formation of the double-helix structure while vibrational energy management is an inherent property of the nucleotide.

KW - DNA

KW - Infrared

KW - Ultrafast spectroscopy

KW - Vibrational coupling

KW - Vibrational relaxation

UR - http://www.scopus.com/inward/record.url?scp=85039969790&partnerID=8YFLogxK

U2 - 10.1016/j.chemphys.2017.12.010

DO - 10.1016/j.chemphys.2017.12.010

M3 - Article

VL - 512

SP - 154

EP - 164

JO - Chemical Physics

JF - Chemical Physics

SN - 0301-0104

ER -