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Effects of a PEG additive on the biomolecular interactions of self-assembled dendron nanostructures

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Effects of a PEG additive on the biomolecular interactions of self-assembled dendron nanostructures. / Barnard, Anna; Calderon, Marcelo; Tschiche, Ariane; Haag, Rainer; Smith, David K.

In: Organic and Biomolecular Chemistry, Vol. 10, No. 42, 14.11.2012, p. 8403-8409.

Research output: Contribution to journalArticlepeer-review

Harvard

Barnard, A, Calderon, M, Tschiche, A, Haag, R & Smith, DK 2012, 'Effects of a PEG additive on the biomolecular interactions of self-assembled dendron nanostructures', Organic and Biomolecular Chemistry, vol. 10, no. 42, pp. 8403-8409. https://doi.org/10.1039/c2ob26584b

APA

Barnard, A., Calderon, M., Tschiche, A., Haag, R., & Smith, D. K. (2012). Effects of a PEG additive on the biomolecular interactions of self-assembled dendron nanostructures. Organic and Biomolecular Chemistry, 10(42), 8403-8409. https://doi.org/10.1039/c2ob26584b

Vancouver

Barnard A, Calderon M, Tschiche A, Haag R, Smith DK. Effects of a PEG additive on the biomolecular interactions of self-assembled dendron nanostructures. Organic and Biomolecular Chemistry. 2012 Nov 14;10(42):8403-8409. https://doi.org/10.1039/c2ob26584b

Author

Barnard, Anna ; Calderon, Marcelo ; Tschiche, Ariane ; Haag, Rainer ; Smith, David K. / Effects of a PEG additive on the biomolecular interactions of self-assembled dendron nanostructures. In: Organic and Biomolecular Chemistry. 2012 ; Vol. 10, No. 42. pp. 8403-8409.

Bibtex - Download

@article{204933f670fa49a081bb48cfcf955942,
title = "Effects of a PEG additive on the biomolecular interactions of self-assembled dendron nanostructures",
abstract = "The ability of self-assembling multivalent DNA-binding dendrons to interact with biological targets is modified by co-assembly with two novel low-molecular-weight cholesterol-functionalised PEG units, one based on triethylene glycol (Chol-PEG-3) and one on an octaethylene glycol (Chol-PEG-8). The addition of either PEG lipid affected the co-assembled nanostructure surface charge and size in different ways depending on the structure of the self-assembling DNA-binding dendron. Co-assembly with Chol-PEG-8 enhanced DNA binding, while Chol-PEG-3 inhibited it. Insertion of Chol-PEG-8 into the aggregates modified their ability to cross a model mucus layer, the details of which can be understood in terms of a balance between the mucoadhesivity due to the surface charge of the nanoscale aggregates and that due to the PEG groups. This study demonstrates that the interaction of nanoscale assemblies with biological systems depends on a number of different factors in a sometimes unpredictable way. Given how simply multiple building blocks can be combined by self-assembly, we conclude that self-assembled multivalent systems have great potential for optimisation to maximise their biological and clinical activity.",
author = "Anna Barnard and Marcelo Calderon and Ariane Tschiche and Rainer Haag and Smith, {David K.}",
year = "2012",
month = nov,
day = "14",
doi = "10.1039/c2ob26584b",
language = "English",
volume = "10",
pages = "8403--8409",
journal = "Organic and Biomolecular Chemistry",
issn = "1477-0520",
publisher = "The Royal Society of Chemistry",
number = "42",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Effects of a PEG additive on the biomolecular interactions of self-assembled dendron nanostructures

AU - Barnard, Anna

AU - Calderon, Marcelo

AU - Tschiche, Ariane

AU - Haag, Rainer

AU - Smith, David K.

PY - 2012/11/14

Y1 - 2012/11/14

N2 - The ability of self-assembling multivalent DNA-binding dendrons to interact with biological targets is modified by co-assembly with two novel low-molecular-weight cholesterol-functionalised PEG units, one based on triethylene glycol (Chol-PEG-3) and one on an octaethylene glycol (Chol-PEG-8). The addition of either PEG lipid affected the co-assembled nanostructure surface charge and size in different ways depending on the structure of the self-assembling DNA-binding dendron. Co-assembly with Chol-PEG-8 enhanced DNA binding, while Chol-PEG-3 inhibited it. Insertion of Chol-PEG-8 into the aggregates modified their ability to cross a model mucus layer, the details of which can be understood in terms of a balance between the mucoadhesivity due to the surface charge of the nanoscale aggregates and that due to the PEG groups. This study demonstrates that the interaction of nanoscale assemblies with biological systems depends on a number of different factors in a sometimes unpredictable way. Given how simply multiple building blocks can be combined by self-assembly, we conclude that self-assembled multivalent systems have great potential for optimisation to maximise their biological and clinical activity.

AB - The ability of self-assembling multivalent DNA-binding dendrons to interact with biological targets is modified by co-assembly with two novel low-molecular-weight cholesterol-functionalised PEG units, one based on triethylene glycol (Chol-PEG-3) and one on an octaethylene glycol (Chol-PEG-8). The addition of either PEG lipid affected the co-assembled nanostructure surface charge and size in different ways depending on the structure of the self-assembling DNA-binding dendron. Co-assembly with Chol-PEG-8 enhanced DNA binding, while Chol-PEG-3 inhibited it. Insertion of Chol-PEG-8 into the aggregates modified their ability to cross a model mucus layer, the details of which can be understood in terms of a balance between the mucoadhesivity due to the surface charge of the nanoscale aggregates and that due to the PEG groups. This study demonstrates that the interaction of nanoscale assemblies with biological systems depends on a number of different factors in a sometimes unpredictable way. Given how simply multiple building blocks can be combined by self-assembly, we conclude that self-assembled multivalent systems have great potential for optimisation to maximise their biological and clinical activity.

UR - http://www.scopus.com/inward/record.url?scp=84867379858&partnerID=8YFLogxK

U2 - 10.1039/c2ob26584b

DO - 10.1039/c2ob26584b

M3 - Article

VL - 10

SP - 8403

EP - 8409

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

SN - 1477-0520

IS - 42

ER -