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Electrospun aniline-tetramer-co-polycaprolactone fibers for conductive, biodegradable scaffolds

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JournalMRS Communications
DateAccepted/In press - 9 Jun 2017
DatePublished (current) - 1 Sep 2017
Issue number3
Volume7
Number of pages8
Pages (from-to)375-382
Original languageEnglish

Abstract

Conjugated polymers have been proposed as promising materials for scaffolds in tissue engineering applications. However, the restricted processability and biodegradability of conjugated polymers limit their use for biomedical applications. Here we synthesized a block-co-polymer of aniline tetramer and PCL (AT-PCL), and processed it into fibrous non-woven scaffolds by electrospinning. We showed that fibronectin (Fn) adhesion was dependent on the AT-PCL oxidative state, with a reduced Fn unfolding length on doped membranes. Furthermore, we demonstrated the cytocompatibility and potential of these membranes to support the growth and osteogenic differentiation of MC3T3-E1 cells over 21 days.

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© Materials Research Society 2017

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