Embedding supervised exercise training for men on androgen deprivation therapy into standard prostate cancer care: a feasibility and acceptability study (the STAMINA trial)

Sophie Reale; Rebecca R Turner; Eileen Sutton; Liz Steed; Stephanie J C Taylor; Dylan Morrissey; Patrick Doherty; Diana M Greenfield; Michelle Collinson; Jenny Hewison; Janet Brown; Saïd Ibeggazene; Malcolm Mason; Derek J Rosario; Liam Bourke

doi:10.1038/s41598-021-91876-y

Embedding supervised exercise training for men on androgen deprivation therapy into standard prostate cancer care: a feasibility and acceptability study (the STAMINA trial)

Sophie Reale, Rebecca R Turner, Eileen Sutton, Liz Steed, Stephanie J C Taylor, Dylan Morrissey, Patrick Doherty, Diana M Greenfield, Michelle Collinson, Jenny Hewison, Janet Brown, Saïd Ibeggazene, Malcolm Mason, Derek J Rosario, Liam Bourke

Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Lifestyle interventions involving exercise training offset the adverse effects of androgen deprivation therapy in men with prostate cancer. Yet provision of integrated exercise pathways in cancer care is sparse. This study assessed the feasibility and acceptability of an embedded supervised exercise training intervention into standard prostate cancer care in a single-arm, multicentre prospective cohort study. Feasibility included recruitment, retention, adherence, fidelity and safety. Acceptability of behaviourally informed healthcare and exercise professional training was assessed qualitatively. Despite the imposition of lockdown for the COVID-19 pandemic, referral rates into and adherence to, the intervention was high. Of the 45 men eligible for participation, 79% (n = 36) received the intervention and 47% (n = 21) completed the intervention before a government mandated national lockdown was enforced in the United Kingdom. Patients completed a mean of 27 min of aerobic exercise per session (SD = 3.48), at 77% heart rate maximum (92% of target dose), and 3 sets of 10 reps of 3 resistance exercises twice weekly for 12 weeks, without serious adverse event. The intervention was delivered by 26 healthcare professionals and 16 exercise trainers with moderate to high fidelity, and the intervention was deemed highly acceptable to patients. The impact of societal changes due to the pandemic on the delivery of this face-to-face intervention remain uncertain but positive impacts of embedding exercise provision into prostate cancer care warrant long-term investigation.

Original language	English
Pages (from-to)	12470
Journal	Scientific Reports
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41598-021-91876-y
Publication status	Published - 14 Jun 2021

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10.1038/s41598-021-91876-y

Reale et al Embedding supervised exercise training for men
© 2021, The Author(s).
Final published version, 945 KBLicence: CC BY

Cite this

Reale, S., Turner, R. R., Sutton, E., Steed, L., Taylor, S. J. C., Morrissey, D., Doherty, P., Greenfield, D. M., Collinson, M., Hewison, J., Brown, J., Ibeggazene, S., Mason, M., Rosario, D. J., & Bourke, L. (2021). Embedding supervised exercise training for men on androgen deprivation therapy into standard prostate cancer care: a feasibility and acceptability study (the STAMINA trial). Scientific Reports, 11(1), 12470. https://doi.org/10.1038/s41598-021-91876-y

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title = "Embedding supervised exercise training for men on androgen deprivation therapy into standard prostate cancer care: a feasibility and acceptability study (the STAMINA trial)",

abstract = "Lifestyle interventions involving exercise training offset the adverse effects of androgen deprivation therapy in men with prostate cancer. Yet provision of integrated exercise pathways in cancer care is sparse. This study assessed the feasibility and acceptability of an embedded supervised exercise training intervention into standard prostate cancer care in a single-arm, multicentre prospective cohort study. Feasibility included recruitment, retention, adherence, fidelity and safety. Acceptability of behaviourally informed healthcare and exercise professional training was assessed qualitatively. Despite the imposition of lockdown for the COVID-19 pandemic, referral rates into and adherence to, the intervention was high. Of the 45 men eligible for participation, 79% (n = 36) received the intervention and 47% (n = 21) completed the intervention before a government mandated national lockdown was enforced in the United Kingdom. Patients completed a mean of 27 min of aerobic exercise per session (SD = 3.48), at 77% heart rate maximum (92% of target dose), and 3 sets of 10 reps of 3 resistance exercises twice weekly for 12 weeks, without serious adverse event. The intervention was delivered by 26 healthcare professionals and 16 exercise trainers with moderate to high fidelity, and the intervention was deemed highly acceptable to patients. The impact of societal changes due to the pandemic on the delivery of this face-to-face intervention remain uncertain but positive impacts of embedding exercise provision into prostate cancer care warrant long-term investigation.",

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Reale, S, Turner, RR, Sutton, E, Steed, L, Taylor, SJC, Morrissey, D, Doherty, P, Greenfield, DM, Collinson, M, Hewison, J, Brown, J, Ibeggazene, S, Mason, M, Rosario, DJ & Bourke, L 2021, 'Embedding supervised exercise training for men on androgen deprivation therapy into standard prostate cancer care: a feasibility and acceptability study (the STAMINA trial)', Scientific Reports, vol. 11, no. 1, pp. 12470. https://doi.org/10.1038/s41598-021-91876-y

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AU - Morrissey, Dylan

AU - Doherty, Patrick

AU - Greenfield, Diana M

AU - Collinson, Michelle

AU - Hewison, Jenny

AU - Brown, Janet

AU - Ibeggazene, Saïd

AU - Mason, Malcolm

AU - Rosario, Derek J

AU - Bourke, Liam

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AB - Lifestyle interventions involving exercise training offset the adverse effects of androgen deprivation therapy in men with prostate cancer. Yet provision of integrated exercise pathways in cancer care is sparse. This study assessed the feasibility and acceptability of an embedded supervised exercise training intervention into standard prostate cancer care in a single-arm, multicentre prospective cohort study. Feasibility included recruitment, retention, adherence, fidelity and safety. Acceptability of behaviourally informed healthcare and exercise professional training was assessed qualitatively. Despite the imposition of lockdown for the COVID-19 pandemic, referral rates into and adherence to, the intervention was high. Of the 45 men eligible for participation, 79% (n = 36) received the intervention and 47% (n = 21) completed the intervention before a government mandated national lockdown was enforced in the United Kingdom. Patients completed a mean of 27 min of aerobic exercise per session (SD = 3.48), at 77% heart rate maximum (92% of target dose), and 3 sets of 10 reps of 3 resistance exercises twice weekly for 12 weeks, without serious adverse event. The intervention was delivered by 26 healthcare professionals and 16 exercise trainers with moderate to high fidelity, and the intervention was deemed highly acceptable to patients. The impact of societal changes due to the pandemic on the delivery of this face-to-face intervention remain uncertain but positive impacts of embedding exercise provision into prostate cancer care warrant long-term investigation.

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DO - 10.1038/s41598-021-91876-y

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