Endocrine disruption and obesity: A current review on environmental obesogens

TY - JOUR

T1 - Endocrine disruption and obesity

T2 - A current review on environmental obesogens

AU - Gupta, Radhika

AU - Kumar, Prashant

AU - Fahmi, Nighat

AU - Garg, Bhaskar

AU - Dutta, Sriparna

AU - Sachar, Shilpee

AU - Matharu, Avtar S.

AU - Vimaleswaran, Karani S.

N1 - Funding Information: The Authors would like to acknowledge that this work is the direct output of a Newton Fund Researcher Links Workshop grant, ID 2018-RLWK10-10480 , between the United Kingdom and India, which allowing researchers to collaborate. The grant is funded by the UK Department for Business, Energy and Industrial Strategy and The Royal Society of Chemistry and delivered by the British Council. For further information, please visit www.newtonfund.ac.uk . Funding Information: Newton Fund Researcher Links workshop grant, ID 2018-RLWK10-10480 . The grant is funded by the UK Department for Business, Energy and Industrial Strategy and the Royal Society of Chemistry and delivered by the British Council. Publisher Copyright: © 2020 The Author(s)

PY - 2020/6/30

Y1 - 2020/6/30

N2 - Obesity represents an important public health concern because it substantially increases the risk of multiple chronic diseases and thereby contributing to a decline in both quality of life and life expectancy. Besides unhealthy diet, physical inactivity and genetic susceptibility, environmental pollutants also contribute to the rising prevalence of obesity epidemic. An environmental obesogen is defined as a chemical that can alter lipid homeostasis to promote adipogenesis and lipid accumulation whereas an endocrine disrupting chemical (EDC) is defined as a synthetic chemical that can interfere with the endocrine function and cause adverse health effects. Many obesogens are EDCs that interfere with normal endocrine regulation of metabolism, adipose tissue development and maintenance, appetite, weight and energy balance. An expanding body of scientific evidence from animal and epidemiological studies has begun to provide links between exposure to EDCs and obesity. Despite the significance of environmental obesogens in the pathogenesis of metabolic diseases, the contribution of synthetic chemical exposure to obesity epidemic remains largely unrecognised. Hence, the purpose of this review is to provide a current update on the evidences from animal and human studies on the role of fourteen environmental obesogens in obesity, a comprehensive view of the mechanisms of action of these obesogens and current green and sustainable chemistry strategies to overcome chemical exposure to prevent obesity. Designing of safer version of obesogens through green chemistry approaches requires a collaborative undertaking to evaluate the toxicity of endocrine disruptors using appropriate experimental methods, which will help in developing a new generation of inherently safer chemicals.

AB - Obesity represents an important public health concern because it substantially increases the risk of multiple chronic diseases and thereby contributing to a decline in both quality of life and life expectancy. Besides unhealthy diet, physical inactivity and genetic susceptibility, environmental pollutants also contribute to the rising prevalence of obesity epidemic. An environmental obesogen is defined as a chemical that can alter lipid homeostasis to promote adipogenesis and lipid accumulation whereas an endocrine disrupting chemical (EDC) is defined as a synthetic chemical that can interfere with the endocrine function and cause adverse health effects. Many obesogens are EDCs that interfere with normal endocrine regulation of metabolism, adipose tissue development and maintenance, appetite, weight and energy balance. An expanding body of scientific evidence from animal and epidemiological studies has begun to provide links between exposure to EDCs and obesity. Despite the significance of environmental obesogens in the pathogenesis of metabolic diseases, the contribution of synthetic chemical exposure to obesity epidemic remains largely unrecognised. Hence, the purpose of this review is to provide a current update on the evidences from animal and human studies on the role of fourteen environmental obesogens in obesity, a comprehensive view of the mechanisms of action of these obesogens and current green and sustainable chemistry strategies to overcome chemical exposure to prevent obesity. Designing of safer version of obesogens through green chemistry approaches requires a collaborative undertaking to evaluate the toxicity of endocrine disruptors using appropriate experimental methods, which will help in developing a new generation of inherently safer chemicals.

KW - Adipogenesis

KW - Endocrine disrupting chemicals

KW - Green chemistry

KW - Obesity

KW - Obesogens

UR - https://www.scopus.com/pages/publications/85104318150

U2 - 10.1016/j.crgsc.2020.06.002

DO - 10.1016/j.crgsc.2020.06.002

M3 - Review article

AN - SCOPUS:85104318150

SN - 2666-0865

VL - 3

JO - Current Research in Green and Sustainable Chemistry

JF - Current Research in Green and Sustainable Chemistry

M1 - 100009

ER -