Endovascular Versus Surgical Treatment in Patients With Carotid Stenosis in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): a Randomised Trial

M.M. Brown; J.M. Bland; J. Rogers

doi:10.1016/S0140-6736(00)04893-5

Endovascular Versus Surgical Treatment in Patients With Carotid Stenosis in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): a Randomised Trial

M.M. Brown, J.M. Bland, J. Rogers

Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Background Percutaneous transluminal angioplasty and stenting (endovascular treatment) can be used to treat carotid stenosis, but risks and benefits are uncertain. We therefore compared endovascular treatment with conventional carotid surgery. Methods In a multicentre clinical trial, we randomly assigned 504 patients with carotid stenosis to endovascular treatment (n=251) or carotid endarterectomy (n=253). For endovascular patients treated successfully, we used stents in 55 (26%) and balloon angioplasty alone in 158 (74%). An independent neurologist followed up patients. Analysis was by intention to treat. Findings The rates of major outcome events within 30 days of first treatment did not differ significantly between endovascular treatment and surgery (6.4% vs 5.9%, respectively, for disabling stroke or death; 10.0% vs 9.9% for any stroke lasting more than 7 days, or death). Cranial neuropathy was reported in 22 (8.7%) surgery patients, but not after endovascular treatment (p

Original language	English
Pages (from-to)	1729-1737
Number of pages	8
Journal	The Lancet
Volume	357
Issue number	9270
DOIs	https://doi.org/10.1016/S0140-6736(00)04893-5
Publication status	Published - 2 Jun 2001

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10.1016/S0140-6736(00)04893-5

http://dx.doi.org/10.1016/S0140-6736(00)04893-5

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title = "Endovascular Versus Surgical Treatment in Patients With Carotid Stenosis in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): a Randomised Trial",

abstract = "Background Percutaneous transluminal angioplasty and stenting (endovascular treatment) can be used to treat carotid stenosis, but risks and benefits are uncertain. We therefore compared endovascular treatment with conventional carotid surgery. Methods In a multicentre clinical trial, we randomly assigned 504 patients with carotid stenosis to endovascular treatment (n=251) or carotid endarterectomy (n=253). For endovascular patients treated successfully, we used stents in 55 (26%) and balloon angioplasty alone in 158 (74%). An independent neurologist followed up patients. Analysis was by intention to treat. Findings The rates of major outcome events within 30 days of first treatment did not differ significantly between endovascular treatment and surgery (6.4% vs 5.9%, respectively, for disabling stroke or death; 10.0% vs 9.9% for any stroke lasting more than 7 days, or death). Cranial neuropathy was reported in 22 (8.7%) surgery patients, but not after endovascular treatment (p",

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T1 - Endovascular Versus Surgical Treatment in Patients With Carotid Stenosis in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): a Randomised Trial

AU - Brown, M.M.

AU - Bland, J.M.

AU - Rogers, J.

PY - 2001/6/2

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N2 - Background Percutaneous transluminal angioplasty and stenting (endovascular treatment) can be used to treat carotid stenosis, but risks and benefits are uncertain. We therefore compared endovascular treatment with conventional carotid surgery. Methods In a multicentre clinical trial, we randomly assigned 504 patients with carotid stenosis to endovascular treatment (n=251) or carotid endarterectomy (n=253). For endovascular patients treated successfully, we used stents in 55 (26%) and balloon angioplasty alone in 158 (74%). An independent neurologist followed up patients. Analysis was by intention to treat. Findings The rates of major outcome events within 30 days of first treatment did not differ significantly between endovascular treatment and surgery (6.4% vs 5.9%, respectively, for disabling stroke or death; 10.0% vs 9.9% for any stroke lasting more than 7 days, or death). Cranial neuropathy was reported in 22 (8.7%) surgery patients, but not after endovascular treatment (p

AB - Background Percutaneous transluminal angioplasty and stenting (endovascular treatment) can be used to treat carotid stenosis, but risks and benefits are uncertain. We therefore compared endovascular treatment with conventional carotid surgery. Methods In a multicentre clinical trial, we randomly assigned 504 patients with carotid stenosis to endovascular treatment (n=251) or carotid endarterectomy (n=253). For endovascular patients treated successfully, we used stents in 55 (26%) and balloon angioplasty alone in 158 (74%). An independent neurologist followed up patients. Analysis was by intention to treat. Findings The rates of major outcome events within 30 days of first treatment did not differ significantly between endovascular treatment and surgery (6.4% vs 5.9%, respectively, for disabling stroke or death; 10.0% vs 9.9% for any stroke lasting more than 7 days, or death). Cranial neuropathy was reported in 22 (8.7%) surgery patients, but not after endovascular treatment (p

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