Endpoint matrix: a conceptual tool to promote consideration of the multiple dimensions of humane endpoints

Vanessa Ashall; Kate Millar

doi:10.14573/altex.1307261

Endpoint matrix: a conceptual tool to promote consideration of the multiple dimensions of humane endpoints

Vanessa Ashall, Kate Millar

Sociology

Research output: Contribution to journal › Article › peer-review

Abstract

This paper proposes a framework to support appropriate application of endpoints in animal experiments. It is recommended that unpredicted endpoints should be explicitly considered alongside scientific endpoints and justifiable endpoints as the three types of endpoint which comprise the "humane." We suggest there is a need for clear identification of each type of endpoint and an understanding of the interactions between these types. The use of an "endpoint matrix" during study planning is proposed to promote methodically sound and consistent definition, determination, and detection of unpredicted, scientific, and justifiable endpoints in animal experiments. It is claimed that the further development and use of this tool will support a more effective and harmonized practical application of humane endpoints for all animal use in line with best practice recommendations.

Original language	English
Pages (from-to)	209-13
Number of pages	5
Journal	ALTEX
Volume	31
Issue number	2
DOIs	https://doi.org/10.14573/altex.1307261
Publication status	Published - 1 May 2014

Keywords

Animal Experimentation/ethics
Animal Testing Alternatives
Animal Welfare/standards
Animals
Animals, Laboratory
Biomedical Research/methods
Endpoint Determination/methods
Ethics, Research
Research Design
Toxicity Tests/methods

Access to Document

10.14573/altex.1307261

Cite this

@article{20442d5e14ed43feb9dae940c053c9a6,

title = "Endpoint matrix: a conceptual tool to promote consideration of the multiple dimensions of humane endpoints",

abstract = "This paper proposes a framework to support appropriate application of endpoints in animal experiments. It is recommended that unpredicted endpoints should be explicitly considered alongside scientific endpoints and justifiable endpoints as the three types of endpoint which comprise the {"}humane.{"} We suggest there is a need for clear identification of each type of endpoint and an understanding of the interactions between these types. The use of an {"}endpoint matrix{"} during study planning is proposed to promote methodically sound and consistent definition, determination, and detection of unpredicted, scientific, and justifiable endpoints in animal experiments. It is claimed that the further development and use of this tool will support a more effective and harmonized practical application of humane endpoints for all animal use in line with best practice recommendations.",

keywords = "Animal Experimentation/ethics, Animal Testing Alternatives, Animal Welfare/standards, Animals, Animals, Laboratory, Biomedical Research/methods, Endpoint Determination/methods, Ethics, Research, Research Design, Toxicity Tests/methods",

author = "Vanessa Ashall and Kate Millar",

year = "2014",

month = may,

day = "1",

doi = "10.14573/altex.1307261",

language = "English",

volume = "31",

pages = "209--13",

journal = "ALTEX",

issn = "1868-596X",

publisher = "Springer",

number = "2",

}

TY - JOUR

T1 - Endpoint matrix

T2 - a conceptual tool to promote consideration of the multiple dimensions of humane endpoints

AU - Ashall, Vanessa

AU - Millar, Kate

PY - 2014/5/1

Y1 - 2014/5/1

N2 - This paper proposes a framework to support appropriate application of endpoints in animal experiments. It is recommended that unpredicted endpoints should be explicitly considered alongside scientific endpoints and justifiable endpoints as the three types of endpoint which comprise the "humane." We suggest there is a need for clear identification of each type of endpoint and an understanding of the interactions between these types. The use of an "endpoint matrix" during study planning is proposed to promote methodically sound and consistent definition, determination, and detection of unpredicted, scientific, and justifiable endpoints in animal experiments. It is claimed that the further development and use of this tool will support a more effective and harmonized practical application of humane endpoints for all animal use in line with best practice recommendations.

AB - This paper proposes a framework to support appropriate application of endpoints in animal experiments. It is recommended that unpredicted endpoints should be explicitly considered alongside scientific endpoints and justifiable endpoints as the three types of endpoint which comprise the "humane." We suggest there is a need for clear identification of each type of endpoint and an understanding of the interactions between these types. The use of an "endpoint matrix" during study planning is proposed to promote methodically sound and consistent definition, determination, and detection of unpredicted, scientific, and justifiable endpoints in animal experiments. It is claimed that the further development and use of this tool will support a more effective and harmonized practical application of humane endpoints for all animal use in line with best practice recommendations.

KW - Animal Experimentation/ethics

KW - Animal Testing Alternatives

KW - Animal Welfare/standards

KW - Animals

KW - Animals, Laboratory

KW - Biomedical Research/methods

KW - Endpoint Determination/methods

KW - Ethics, Research

KW - Research Design

KW - Toxicity Tests/methods

U2 - 10.14573/altex.1307261

DO - 10.14573/altex.1307261

M3 - Article

C2 - 24794004

SN - 1868-596X

VL - 31

SP - 209

EP - 213

JO - ALTEX

JF - ALTEX

IS - 2

ER -