Enhanced pro-inflammatory cytokine responses following Toll-like-receptor ligation in Schistosoma haematobium-infected schoolchildren from rural Gabon

Lynn Meurs; Lucja Labuda; Abena Serwaa Amoah; Moustapha Mbow; Ulysse Ateba Ngoa; Daniel Adjei Boakye; Souleymane Mboup; Tandakha Ndiaye Dièye; Adrian P Mountford; Joseph D Turner; Peter Gottfried Kremsner; Katja Polman; Maria Yazdanbakhsh; Ayola Akim Adegnika

doi:10.1371/journal.pone.0024393

Enhanced pro-inflammatory cytokine responses following Toll-like-receptor ligation in Schistosoma haematobium-infected schoolchildren from rural Gabon

Lynn Meurs, Lucja Labuda, Abena Serwaa Amoah, Moustapha Mbow, Ulysse Ateba Ngoa, Daniel Adjei Boakye, Souleymane Mboup, Tandakha Ndiaye Dièye, Adrian P Mountford, Joseph D Turner, Peter Gottfried Kremsner, Katja Polman, Maria Yazdanbakhsh, Ayola Akim Adegnika

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Schistosoma infection is thought to lead to down-regulation of the host's immune response. This has been shown for adaptive immune responses, but the effect on innate immunity, that initiates and shapes the adaptive response, has not been extensively studied. In a first study to characterize these responses, we investigated the effect of Schistosoma haematobium infection on cytokine responses of Gabonese schoolchildren to a number of Toll-like receptor (TLR) ligands.

Original language	English
Article number	e24393
Pages (from-to)	e24393
Journal	PLoS ONE
Volume	6
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0024393
Publication status	Published - 8 Sept 2011

Keywords

Adolescent
Animals
Cells, Cultured
Child
Cytokines
Female
Humans
Inflammation Mediators
Leukocytes, Mononuclear
Ligands
Male
Rural Population
Schistosoma haematobium
Schistosomiasis haematobia
Schools
Toll-Like Receptors

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10.1371/journal.pone.0024393

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Meurs, L., Labuda, L., Amoah, A. S., Mbow, M., Ngoa, U. A., Boakye, D. A., Mboup, S., Dièye, T. N., Mountford, A. P., Turner, J. D., Kremsner, P. G., Polman, K., Yazdanbakhsh, M., & Adegnika, A. A. (2011). Enhanced pro-inflammatory cytokine responses following Toll-like-receptor ligation in Schistosoma haematobium-infected schoolchildren from rural Gabon. PLoS ONE, 6(9), e24393. Article e24393. https://doi.org/10.1371/journal.pone.0024393

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abstract = "Schistosoma infection is thought to lead to down-regulation of the host's immune response. This has been shown for adaptive immune responses, but the effect on innate immunity, that initiates and shapes the adaptive response, has not been extensively studied. In a first study to characterize these responses, we investigated the effect of Schistosoma haematobium infection on cytokine responses of Gabonese schoolchildren to a number of Toll-like receptor (TLR) ligands.",

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author = "Lynn Meurs and Lucja Labuda and Amoah, {Abena Serwaa} and Moustapha Mbow and Ngoa, {Ulysse Ateba} and Boakye, {Daniel Adjei} and Souleymane Mboup and Di{\`e}ye, {Tandakha Ndiaye} and Mountford, {Adrian P} and Turner, {Joseph D} and Kremsner, {Peter Gottfried} and Katja Polman and Maria Yazdanbakhsh and Adegnika, {Ayola Akim}",

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Meurs, L, Labuda, L, Amoah, AS, Mbow, M, Ngoa, UA, Boakye, DA, Mboup, S, Dièye, TN, Mountford, AP, Turner, JD, Kremsner, PG, Polman, K, Yazdanbakhsh, M & Adegnika, AA 2011, 'Enhanced pro-inflammatory cytokine responses following Toll-like-receptor ligation in Schistosoma haematobium-infected schoolchildren from rural Gabon', PLoS ONE, vol. 6, no. 9, e24393, pp. e24393. https://doi.org/10.1371/journal.pone.0024393

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AU - Labuda, Lucja

AU - Amoah, Abena Serwaa

AU - Mbow, Moustapha

AU - Ngoa, Ulysse Ateba

AU - Boakye, Daniel Adjei

AU - Mboup, Souleymane

AU - Dièye, Tandakha Ndiaye

AU - Mountford, Adrian P

AU - Turner, Joseph D

AU - Kremsner, Peter Gottfried

AU - Polman, Katja

AU - Yazdanbakhsh, Maria

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KW - Ligands

KW - Male

KW - Rural Population

KW - Schistosoma haematobium

KW - Schistosomiasis haematobia

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Enhanced pro-inflammatory cytokine responses following Toll-like-receptor ligation in Schistosoma haematobium-infected schoolchildren from rural Gabon

Abstract

Keywords

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Other files and links

SCHISTOINIR: Innate immune responses and immunoregulatgion in schistomiasis

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Enhanced pro-inflammatory cytokine responses following Toll-like-receptor ligation in Schistosoma haematobium-infected schoolchildren from rural Gabon

Abstract

Keywords

Access to Document

Other files and links

Projects

SCHISTOINIR: Innate immune responses and immunoregulatgion in schistomiasis

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