Enzymatic synthesis of unsaturated polyesters: functionalization and reversibility of the aza-Michael addition of pendants

Alessandro Pellis, Polly Ann Hanson, James William Comerford, James Hanley Clark, Thomas James Farmer

Research output: Contribution to journalArticlepeer-review


With society's increasing awareness of the problems caused by plastic pollution, the switch to renewable, biodegradable materials is nowadays a must for several producers and consumers. In the present work, the biocatalyzed synthesis of fully renewable polyesters containing lateral vinyl functionalities derived from itaconic, fumaric and maleic acid is presented. Here, an environmentally friendly synthesis was therefore combined with the possibility of obtaining materials that could be functionalized via post-polymerization modifications such as the aza-Michael additions of diethylamine. Moreover, the possibility of reversing the polymer's post-functionalization via a temperature-driven process to obtain free lateral vinyl groups again is also described and analyzed for several polymers based on itaconates and 1,4-butanediol, 1,6-hexanediol and 1,8-octanediol. The collected results set the basis for the development of switchable polymers where pharmaceuticals or other chemicals/polymers can be coupled to the polymeric backbone and released upon changing the material's conditions.
Original languageEnglish
Pages (from-to)843-851
Number of pages9
JournalPolymer Chemistry
Issue number7
Early online date5 Jan 2019
Publication statusPublished - 21 Feb 2019

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