Epi-cyclophellitol cyclosulfate, a mechanism-based ER α-glucosidase II inhibitor, blocks replication of SARS-CoV-2 and other coronaviruses

Melissa Thaler; Tim P. Ofman; Ken Kok; Jurriaan J.A. Heming; Elisha Moran; Isabelle Pickles; Anouk A. Leijs; Adrianus M. C. H. van den Nieuwendijk; Richard J. B. H. N van den Berg; Gijs Ruijgrok; Zach Armstrong; Clarisse Salgado-Benvindo; Dennis K. Ninaber; Eric J. Snijder; Constant A. A. van Boeckel; Marta Artola; Gideon J. Davies; Herman S. Overkleeft; Martijn J. van Hemert

Epi-cyclophellitol cyclosulfate, a mechanism-based ER α-glucosidase II inhibitor, blocks replication of SARS-CoV-2 and other coronaviruses

Melissa Thaler, Tim P. Ofman, Ken Kok, Jurriaan J.A. Heming, Elisha Moran, Isabelle Pickles, Anouk A. Leijs, Adrianus M. C. H. van den Nieuwendijk, Richard J. B. H. N van den Berg, Gijs Ruijgrok, Zach Armstrong, Clarisse Salgado-Benvindo, Dennis K. Ninaber, Eric J. Snijder, Constant A. A. van Boeckel, Marta Artola, Gideon J. Davies, Herman S. Overkleeft, Martijn J. van Hemert

Chemistry

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1594–1608
Journal	ACS Central Science
Volume	10
Issue number	8
Publication status	Accepted/In press - 9 Jul 2024

Bibliographical note

This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

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ACS-CentSci-09July-smaller
This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.
Accepted author manuscript, 9.15 MBLicence: CC BY

1 Finished
2 Active

CARBOCENTRE: Activity-Based Profiling of Glycoprocessing Enzymes for Human Health and a Sustainable Society
Davies, G. J. (Principal investigator)
EUROPEAN COMMISSION
1/06/21 → 31/05/27
Project: Research project (funded) › Research
RS Research Professorship
Davies, G. J. (Principal investigator)
THE ROYAL SOCIETY
1/01/17 → 31/12/26
Project: Research project (funded) › Research
Application of activity-based glycosidase probes for mechanism, enzyme discovery and clinical diagnosis
Davies, G. J. (Principal investigator)
BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL)
1/01/18 → 31/12/21
Project: Research project (funded) › Research

Cite this

Thaler, M., Ofman, T. P., Kok, K., Heming, J. J. A., Moran, E., Pickles, I., Leijs, A. A., Nieuwendijk, A. M. C. H. V. D., Berg, R. J. B. H. N. V. D., Ruijgrok, G., Armstrong, Z., Salgado-Benvindo, C., Ninaber, D. K., Snijder, E. J., Boeckel, C. A. A. V., Artola, M., Davies, G. J., Overkleeft, H. S., & Hemert, M. J. V. (Accepted/In press). Epi-cyclophellitol cyclosulfate, a mechanism-based ER α-glucosidase II inhibitor, blocks replication of SARS-CoV-2 and other coronaviruses. ACS Central Science, 10(8), 1594–1608.

@article{3b392ec5c3374fbb8e24fdec5f60bc37,

title = "Epi-cyclophellitol cyclosulfate, a mechanism-based ER α-glucosidase II inhibitor, blocks replication of SARS-CoV-2 and other coronaviruses",

author = "Melissa Thaler and Ofman, {Tim P.} and Ken Kok and Heming, {Jurriaan J.A.} and Elisha Moran and Isabelle Pickles and Leijs, {Anouk A.} and Nieuwendijk, {Adrianus M. C. H. van den} and Berg, {Richard J. B. H. N van den} and Gijs Ruijgrok and Zach Armstrong and Clarisse Salgado-Benvindo and Ninaber, {Dennis K.} and Snijder, {Eric J.} and Boeckel, {Constant A. A. van} and Marta Artola and Davies, {Gideon J.} and Overkleeft, {Herman S.} and Hemert, {Martijn J. van}",

note = "This is an author-produced version of the published paper. Uploaded in accordance with the publisher{\textquoteright}s self-archiving policy. Further copying may not be permitted; contact the publisher for details.",

year = "2024",

month = jul,

day = "9",

language = "English",

volume = "10",

pages = "1594–1608",

journal = "ACS Central Science",

issn = "2374-7943",

publisher = "American Chemical Society",

number = "8",

}

Thaler, M, Ofman, TP, Kok, K, Heming, JJA, Moran, E, Pickles, I, Leijs, AA, Nieuwendijk, AMCHVD, Berg, RJBHNVD, Ruijgrok, G, Armstrong, Z, Salgado-Benvindo, C, Ninaber, DK, Snijder, EJ, Boeckel, CAAV, Artola, M, Davies, GJ, Overkleeft, HS & Hemert, MJV 2024, 'Epi-cyclophellitol cyclosulfate, a mechanism-based ER α-glucosidase II inhibitor, blocks replication of SARS-CoV-2 and other coronaviruses', ACS Central Science, vol. 10, no. 8, pp. 1594–1608.

TY - JOUR

T1 - Epi-cyclophellitol cyclosulfate, a mechanism-based ER α-glucosidase II inhibitor, blocks replication of SARS-CoV-2 and other coronaviruses

AU - Thaler, Melissa

AU - Ofman, Tim P.

AU - Kok, Ken

AU - Heming, Jurriaan J.A.

AU - Moran, Elisha

AU - Pickles, Isabelle

AU - Leijs, Anouk A.

AU - Nieuwendijk, Adrianus M. C. H. van den

AU - Berg, Richard J. B. H. N van den

AU - Ruijgrok, Gijs

AU - Armstrong, Zach

AU - Salgado-Benvindo, Clarisse

AU - Ninaber, Dennis K.

AU - Snijder, Eric J.

AU - Boeckel, Constant A. A. van

AU - Artola, Marta

AU - Davies, Gideon J.

AU - Overkleeft, Herman S.

AU - Hemert, Martijn J. van

N1 - This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

PY - 2024/7/9

Y1 - 2024/7/9

M3 - Article

SN - 2374-7943

VL - 10

SP - 1594

EP - 1608

JO - ACS Central Science

JF - ACS Central Science

IS - 8

ER -

Epi-cyclophellitol cyclosulfate, a mechanism-based ER α-glucosidase II inhibitor, blocks replication of SARS-CoV-2 and other coronaviruses

Bibliographical note

Access to Document

Projects

CARBOCENTRE: Activity-Based Profiling of Glycoprocessing Enzymes for Human Health and a Sustainable Society

RS Research Professorship

Application of activity-based glycosidase probes for mechanism, enzyme discovery and clinical diagnosis

Cite this